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首页> 外文期刊>Chinese science bulletin >Tracing neuronal tracts in the olfactory pathway of rat and detecting ischemic core in a rat model of focal ischemia using manganese enhanced magnetic resonance imaging
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Tracing neuronal tracts in the olfactory pathway of rat and detecting ischemic core in a rat model of focal ischemia using manganese enhanced magnetic resonance imaging

机译：使用锰增强磁共振成像在大鼠嗅觉途径中追踪神经束并检测局部缺血模型中的缺血核心

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Manganese enhanced magnetic resonance imaging (MRI) is a novel neuroimaging technique that can be used in vivo to trace neuronai tract and to study brain functions dynamically. In this study, manganese enhanced MRI was used to trace the neuronai tracts between the laminar structures of the olfactory bulb (OB) in rat and to study the so-called "calcium overload" phenomenon in a rat model of cerebral ischemia. High spatial resolution images of the OB were obtained and used to measure the transportation rate of Mn~(2+) among the laminar structures of the OB, which was shown to be approximately 0.2 mm/h under resting condition. In the rat focal ischemia study, it was found that the total area of brain regions with Mn~(2+) accumulation (representing brain regions with calcium overload) was only 55 percent +-15 percent of the area of the ischemic brain regions shown by diffusion-weighted imaging (DWI). Manganese enhanced MRI might be more accurate than DWI in detecting the ischemic core at the early stage of experimental cerebral ischemia.
机译：锰增强磁共振成像（MRI）是一种新型的神经成像技术，可以在体内用于追踪神经元和动态研究脑功能。在这项研究中，锰增强MRI用于追踪大鼠嗅球（OB）的层状结构之间的神经元，并研究大鼠脑缺血模型中的所谓“钙超载”现象。获得了OB的高空间分辨率图像，并将其用于测量OB的层状结构之间Mn〜（2+）的传输速率，在静止条件下，该速率约为0.2 mm / h。在大鼠局灶性缺血研究中，发现具有Mn〜（2+）积聚的脑区域的总面积（代表钙超载的脑区域）仅占所示缺血脑区域的55％+ -15％通过扩散加权成像（DWI）。在实验性脑缺血的早期，锰增强的MRI可能比DWI更准确。

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