Spike protein homology between the SARS-associated virus and murine hepatitis virus implies existence of a putative receptor-binding region

LU Yun; CHEN Yinghua

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Spike protein homology between the SARS-associated virus and murine hepatitis virus implies existence of a putative receptor-binding region

机译：SARS相关病毒和鼠肝炎病毒之间的穗蛋白同源性暗示存在假定的受体结合区

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Coronavirus has been determined to be the cause of the recent outbreak of severe acute respiratory syndrome (SARS). Human coronavirus 229E had been studied well and its receptor-binding domain was restricted to aa417 -547 of S protein. However, this region has no homology with the newly separated SARS-associated virus (Hong Kong isolate CUHK-W1). Then we analyzed the phylogenesis of S1 subunit of the coronavirus spike protein (SARS-associated virus, Hong Kong isolate CUHK-W1). Interestingly, the highest homology between murine hepatitis virus (MHV) and SARS-associated coronavirus was found. And the important sites (aa62-65 and aa214-216) on the spike protein of MHV with receptor-binding capacity were highly conservative in comparison with the newly separated SARS-associated virus (the corresponding sites are aa51-54 and aa195 -197). These results from bioinformatics analysis might help us to study the receptor-binding sites of SARS-associated virus and the mechanism of the virus entry into the target cell, and design antiviral drugs and potent vaccines.

机译：已确定冠状病毒是近期爆发的严重急性呼吸道综合症（SARS）的原因。人类冠状病毒229E已被很好地研究，其受体结合域仅限于S蛋白的aa417 -547。但是，该区域与新分离出的SARS相关病毒（香港分离株CUHK-W1）没有同源性。然后，我们分析了冠状病毒刺突蛋白（SARS相关病毒，香港分离株CUHK-W1）的S1亚基的系统发育。有趣的是，鼠肝炎病毒（MHV）与SARS相关冠状病毒之间的同源性最高。与新分离的SARS相关病毒相比，MHV穗蛋白上具有受体结合能力的重要位点（aa62-65和aa214-216）高度保守（相应位点为aa51-54和aa195 -197）。。生物信息学分析的这些结果可能有助于我们研究SARS相关病毒的受体结合位点以及该病毒进入靶细胞的机制，并设计抗病毒药物和有效疫苗。

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来源
《Chinese science bulletin》 |2003年第11期|p.1115-1117|共3页
作者
LU Yun; CHEN Yinghua;
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作者单位

Laboratory of Immunology, Department of Biology, Tsinghua University;

Beijing 100084,China;

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原文格式 PDF
正文语种 eng
中图分类自然科学现状及发展;
关键词
SARS-associated virus; receptor-binding sites; human coronavirus; murine hepatitis virus;

机译：SARS相关病毒;受体结合位点;人冠状病毒;鼠肝炎病毒;

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1. Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors. [J] . Liu S, Xiao G, Chen Y, The Lancet . 2004,第9413期

机译：SARS相关冠状病毒的刺突蛋白中七肽重复序列1和2区域之间的相互作用：对病毒融合机制和融合抑制剂鉴定的影响。
2. Substitutions of conserved amino acids in the receptor-binding domain of the spike glycoprotein affect utilization of murine CEACAM1a by the murine coronavirus MHV-A59. [J] . Thackray LB, Turner BC, Holmes KV Virology . 2005,第1期

机译：峰值糖蛋白的受体结合结构域中保守氨基酸的取代影响鼠冠状病毒MHV-A59对鼠CEACAM1a的利用。
3. Identification of murine CD8 T cell epitopes in codon-optimized SARS-associated coronavirus spike protein. [J] . Zhi Y, Kobinger GP, Jordan H, Virology . 2005,第1期

机译：密码子优化的SARS相关冠状病毒刺突蛋白中的小鼠CD8 T细胞表位的鉴定。
4. Interaction with membrane model systems of synthetic putative fusion peptides derived from hepatitis G virus E2 protein [C] . Isabel Haro, Jordi Casas, Cristina Larios International Peptide Symposium;European Peptide Symposium . 2005

机译：与乙型肝炎病毒E2蛋白衍生的合成推定融合肽膜模型系统的相互作用
5. Chimeric orthohepadnavirus core particles for oral delivery of vaccines: Part I. Transformation of tobacco plants with a gene encoding a c-terminus truncated hepatitis B virus core protein. Part II. Construction of a woodchuck hepatitis virus core protein-based universal epitope carrier and test expression in Escherichia coli. [D] . Callaghan, Maximilian W. 2001

机译：用于口服递送疫苗的嵌合正丙肝病毒核心颗粒：第一部分。用编码c末端截短的乙型肝炎病毒核心蛋白的基因转化烟草植物。第二部分基于土拨鼠肝炎病毒核心蛋白的通用表位载体的构建和大肠杆菌中的表达测试。
6. Spike protein homology between the SARS-associated virus and murine hepatitis virus implies existence of a putative receptor-binding region [O] . Yun Lu, Yinghua Chen -1

机译：SARS相关病毒和鼠肝炎病毒之间的穗状蛋白同源性表明存在假定的受体结合区
7. Homologies between a brain-specific identifier (ID) sequence and regions of Harvey murine sarcoma virus and Rous sarcoma virus genomes Putative role of identifier sequences in the tissue specificity of malignant transformation by RNA tumor viruses [O] . Minárovits János, Kovács Zoltán, Földes István 1984

机译：脑特异性标识符（ID）序列与哈维鼠肉瘤病毒和劳斯肉瘤病毒基因组区域之间的同源性标识符序列在RNA肿瘤病毒恶性转化的组织特异性中的假定作用

Spike protein homology between the SARS-associated virus and murine hepatitis virus implies existence of a putative receptor-binding region

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