On the structure of AP-4 responsive element in the LTR of Jembrana disease virus

LIU Zijing; YIN Hongyan; DENG Gang; YUAN Yuhua; WANG Jinzhong; GENG Yunqi; CHEN Qimin

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On the structure of AP-4 responsive element in the LTR of Jembrana disease virus

机译：脑膜炎病毒LTR中AP-4反应元件的结构

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Previous studies with deletion and sequence analysis of JDV LTR showed that there is a putative AP-4 responsive element in LTR. By antisense transient assay and gel shifting assay, we for the first time demonstrated that AP-4 modulated JDV gene expression by binding DNA directly to bovine cells. The results, derived from site-directed mutagenesis experiments, suggest that the six base pairs of AP-4 binding site (CAGCTG) have different effects on JDV gene expression. When the first two base pairs changed to GC, JDV gene expression is severely decreased.

机译：先前对JDV LTR的缺失和序列分析的研究表明，LTR中存在推定的AP-4响应元件。通过反义瞬时分析和凝胶迁移分析，我们首次证明AP-4通过将DNA直接与牛细胞结合来调节JDV基因表达。从定点诱变实验得出的结果表明，AP-4结合位点的六个碱基对（CAGCTG）对JDV基因表达的影响不同。当前两个碱基对变为GC时，JDV基因表达严重降低。

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来源
《Chinese science bulletin》 |2003年第12期|p.1247-1250|共4页
作者
LIU Zijing; YIN Hongyan; DENG Gang; YUAN Yuhua; WANG Jinzhong; GENG Yunqi; CHEN Qimin;
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作者单位

College of Life Sciences, Nankai University, Tianjin 300071, China;

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原文格式 PDF
正文语种 eng
中图分类自然科学现状及发展;
关键词
JDV; cellular factor AP-4; trans -activator (Tat); LTR; site-directed mutagenesis;

机译：JDV;细胞因子AP-4;反式激活子（Tat）;LTR;定点诱变;

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On the structure of AP-4 responsive element in the LTR of Jembrana disease virus

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