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Effects of the rare earth ions on bone resorbing function of rabbit mature osteoclasts in vitro

机译：稀土离子对兔成熟破骨细胞体外骨吸收功能的影响

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The effects of rare earth ions on bone resorbing function of osteoclasts were studied by culturing Japanese white rabbit osteoclasts on bone slices. In order to evaluate the activity of osteoclasts, the number and surface areas of lacunae were measured by photomicrography and image analysis, and the calcium concentration in the supernatant was measured by the atomic absorption spectrometry. The lacunae morphology was observed under a scanning electron microscope. The results indicated that La~(3+),Sm~(3+) and Er~(3+) at the concentration of 1.00 X 10~(-5), 1.00 X 10~(-6) and 1.00X 10~(-7)mol/L and Nd~(3+), Gd~(3+) and Dy~(3+) at the concentration of 1.00 X 10~(-5) and 1.00 X 10~(-6) mol/L inhibited ostcoclastic activity as indicated by the dose-dependent reduction in the numbers and surface areas of the lacunae (P<0.01). On the contrary, the number and surface areas of lanunae were increased and osteoclastic hone resorbing function was significantly enhanced by La~(3+), Sm~(3+) and Er~(3+) at the concentration of 1.00 X 10~(-8) mol/L and Nd~(3+) Gd~(3+) and Dy~(3+) at the concentration of 1.00 X l0~(-7) mol/L (P<0.01). Nd~(3+), Gd~(3+) and Dy~(3+) had no effect on osteoclastic bone resorption function at concentrations as low as 1.00 X 10~(-8)mol/L (P>0.05). It is suggested that the effects of rare earth ions on osteoclastic bone resorption are bidirectional, depending on concentrations and species.
机译：通过在骨切片上培养日本白兔破骨细胞，研究了稀土离子对破骨细胞骨吸收功能的影响。为了评估破骨细胞的活性，通过显微照相和图像分析来测量腔隙的数量和表面积，并且通过原子吸收光谱法测量上清液中的钙浓度。在扫描电子显微镜下观察腔的形态。结果表明，La〜（3 +），Sm〜（3+）和Er〜（3+）的浓度分别为1.00 X 10〜（-5），1.00 X 10〜（-6）和1.00X 10〜 （-7）mol / L和Nd〜（3 +），Gd〜（3+）和Dy〜（3+）的浓度分别为1.00 X 10〜（-5）和1.00 X 10〜（-6）mol / L抑制了破骨细胞的活性，这是腔的数量和表面积的剂量依赖性降低所表明的（P <0.01）。相反，浓度为1.00 X 10〜时，La〜（3 +），Sm〜（3+）和Er〜（3+）会增加lanunae的数量和表面积，并显着增强破骨细胞的骨吸收能力。 （-8）mol / L和Nd〜（3+）Gd〜（3+）和Dy〜（3+）的浓度为1.00 X 10〜（-7）mol / L（P <0.01）。 Nd〜（3 +），Gd〜（3+）和Dy〜（3+）在低至1.00 X 10〜（-8）mol / L的浓度下对破骨细胞的骨吸收功能没有影响（P> 0.05）。建议稀土离子对破骨细胞骨吸收的影响是双向的，具体取决于浓度和种类。

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