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首页> 外文期刊>Journal of rare earths >Effects of Lanthanum on Bone Resorbing Activity of Rabbit Mature Osteoclasts Co-Cultured with Osteoblasts
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Effects of Lanthanum on Bone Resorbing Activity of Rabbit Mature Osteoclasts Co-Cultured with Osteoblasts

机译：镧对成骨细胞联合培养的兔成熟破骨细胞骨吸收活性的影响

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摘要

The effects of lanthanum ( III) on the bone resorbing activity of rabbit mature osteoblasts (DCs) in the presence of osteoblasts (OBs) were studied in vitro by measuring the number and area of absorption pits. La(III) at concentrations ranging from 1.00 x 10~(-5) to 1.00 x 10~9-8) mol L~(-1) show no effect on mature OC number (P>0.05). In the OC-OB co-culture systems without La( IE ) , osteoblasts alone did not influence the pit number and area whether the two kinds of cells were in contact or not (P > 0.05) . Under the OC-OB not-in-contact condition, the effect of La( III ) on the bone-resorbing activity of OCs was similar to that of La( HI) in the absence of OBs (P > 0.05) . However, while OCs were in direct contact with OBs, the inhibitory effects of La( M ) on OCs' bone-resorbing activity decreased at the concentrations of 1.00 X 10~(-5), 1.00 x 10~(-6) and 1.00 X 10~(-7) mol L~(-1), and the promotion effects increased at 1.00 x 10~(-8) mol L~(-1) (P<0.05). The results suggest that direct cell-cell contact between OC and OB be essential for OBs to play their role in regulating the response of OCs to La(III ).
机译：通过测量吸收坑的数量和面积，研究了镧（III）对成骨细胞（OB）存在下兔成熟成骨细胞（DC）骨吸收活性的影响。 La（III）的浓度范围从1.00 x 10〜（-5）到1.00 x 10〜9-8）mol L〜（-1）对成熟OC值没有影响（P> 0.05）。在没有La（IE）的OC-OB共培养系统中，无论两种细胞是否接触，单独的成骨细胞都不会影响窝数和面积（P> 0.05）。在OC-OB非接触条件下，La（III）对OCs的骨吸收活性的影响与没有OBs时La（HI）的相似（P> 0.05）。然而，当OCs与OBs直接接触时，La（M）对OCs的骨吸收活性的抑制作用在1.00 X 10〜（-5），1.00 x 10〜（-6）和1.00时降低。 X 10〜（-7）mol L〜（-1），促进效果在1.00 x 10〜（-8）mol L〜（-1）时增加（P <0.05）。结果表明，OC与OB之间直接的细胞接触对于OB在调节OC对La（III）的反应中发挥作用至关重要。

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