Important amino acid in the hemagglutinin glycoprotein of measles virus(MV)that governs hemadsorption

Li Lingyun; Qi Yipeng; Michiko Watanabe

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Important amino acid in the hemagglutinin glycoprotein of measles virus(MV)that governs hemadsorption

机译：麻疹病毒（MV）的血凝素糖蛋白中控制吸血的重要氨基酸

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Two strains of measles virus IMA and SMD that were isolated using B95a cell line show hemadsorption negative. After adaptation to Vero cells, these strains gain the ability to ag- glutinate AGM-RBC and show hemadsorption positive. Sequence analysis of these two kinds of virus reveals that the two strains all have a Ser(HAD negative)to Gly(HAD positive)multation at position 546 in the H protein. Site-directed mutagenesis and expression in COS cells were used toconfirm that the mutation Ser→Gly is responsible for hemadsorption alteration.

机译：使用B95a细胞系分离的两株麻疹病毒IMA和SMD菌株显示吸血阴性。适应Vero细胞后，这些菌株便具有凝集AGM-RBC的能力，并显示出吸血阳性。这两种病毒的序列分析表明，这两种菌株在H蛋白的546位均具有Ser（HAD阴性）至Gly（HAD阳性）的突变。通过定点诱变和在COS细胞中的表达来证实Ser→Gly突变是引起吸血改变的原因。

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《Chinese science bulletin》 |1999年第7期|p.612-617|共6页
作者
Li Lingyun; Qi Yipeng; Michiko Watanabe;
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原文格式 PDF
正文语种 eng
中图分类自然科学现状及发展;
关键词
H protein; CD46 receptor; hemadsorption;

机译：H蛋白;CD46受体;溶血;

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专利

1. A novel amino acid position in hemagglutinin glycoprotein of measles virus is responsible for hemadsorption and CD46 binding. [J] . Li L, Qi Y Archives of virology . 2002,第4期

机译：麻疹病毒血凝素糖蛋白中一个新的氨基酸位置负责吸血和CD46结合。
2. Amino acid change 335 E to K affects the sialic-acid-binding and neuraminidase activities of Urabe AM9 mumps virus hemagglutinin-neuraminidase glycoprotein. [J] . Reyes-Leyva J, Banos R, Borraz-Arguello M, Microbes and infection . 2007,第2期

机译：氨基酸335 E到K的变化会影响Urabe AM9腮腺炎病毒血凝素神经氨酸酶糖蛋白的唾液酸结合和神经氨酸酶活性。
3. Amino acid substitutions at position 481 differently affect the ability of the measles virus hemagglutinin to induce cell fusion in monkey and marmoset cells co-expressing the fusion protein. [J] . Xie M, Tanaka K, Ono N, Archives of virology . 1999,第9期

机译：位置481处的氨基酸取代会不同地影响麻疹病毒血凝素诱导猴和and猴细胞共表达融合蛋白的细胞融合的能力。
4. Genetic and antigenic analysis of the hemagglutinin of recent swine influenza virus isolates utilizing a unique software program comparing amino acid substitutions in immunogenic sites [C] . T. Oleson, B. Hause, D.L. Stine, Annual Meeting of the American Association of Swine Veterinarians . 2010

机译：利用独特的软件计划将氨基酸取代在免疫原性位点中的独特软件程序分离素血凝素的遗传和抗原分析
5. Identification and Analysis of Amino Acid Substitutions in Ebola Virus Glycoprotein Fusion Loop That Interfere With Infection. [D] . Wilkes, Sean Lowell. 2012

机译：埃博拉病毒糖蛋白融合环干扰感染的氨基酸取代的鉴定和分析。
6. Identification of two amino acids in the hemagglutinin glycoprotein of measles virus (MV) that govern hemadsorption HeLa cell fusion and CD46 downregulation: phenotypic markers that differentiate vaccine and wild-type MV strains. [O] . V Lecouturier, J Fayolle, M Caballero, 1996

机译：识别控制吸血HeLa细胞融合和CD46下调的麻疹病毒（MV）血凝素糖蛋白中的两个氨基酸：区分疫苗和野生型MV菌株的表型标记。
7. Identification of two amino acids in the hemagglutinin glycoprotein of measles virus (MV) that govern hemadsorption, HeLa cell fusion, and CD46 downregulation: phenotypic markers that differentiate vaccine and wild-type MV strains [O] . V Lecouturier, J Fayolle, M Caballero, 1996

机译：鉴定麻疹病毒（MV）血凝素糖蛋白的两个氨基酸，用于治理血液吸附，HELA细胞融合和CD46下调：分化疫苗和野生型MV菌株的表型标志物

Important amino acid in the hemagglutinin glycoprotein of measles virus(MV)that governs hemadsorption

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