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首页> 外文期刊>Chromatographia >UPLC–MS–MS Analysis of Quetiapine and Its Two Active Metabolites, 7-Hydroxyquetiapine and 7-Hydroxy- N -dealkylquetiapine, in Rat Plasma and Cerebrospinal Fluid
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UPLC–MS–MS Analysis of Quetiapine and Its Two Active Metabolites, 7-Hydroxyquetiapine and 7-Hydroxy- N -dealkylquetiapine, in Rat Plasma and Cerebrospinal Fluid

机译：UPLC-MS-MS分析大鼠血浆和脑脊液中的喹硫平及其两种活性代谢物7-羟基喹硫平和7-羟基-N-脱烷基喹硫平

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摘要

Quetiapine (QP) is an antipsychotic agent widely used to treat a variety of human psychotic disorders. 7-Hydroxyquetiapine (QPOH) and 7-hydroxy-N-dealkylquetiapine (QPND) are its two active metabolites. A rapid and sensitive ultra-performance liquid chromatographic–tandem mass spectrometric method has been developed for analysis of the three agents in plasma and cerebrospinal fluid (CSF) from rats. The assay was based on liquid–liquid extraction of 100-μL samples. The methods were validated for QP, QPOH, and QPND in both types of sample. Limits of detection (LOD) in plasma were 0.02, 0.01, and 0.02 ng mL−1 for QP, QPOH, and QPND, respectively; in CSF samples the respective values were 0.02, 0.01, and 0.01 ng mL−1. The utility of the method was demonstrated by analysis of the pharmacokinetics and CSF distribution properties of QP and its two active metabolites in the plasma and CSF in rats.
机译：喹硫平（QP）是一种抗精神病药，广泛用于治疗各种人类精神病。 7-羟基喹硫平（QPOH）和7-羟基-N-脱烷基喹硫平（QPND）是其两种活性代谢产物。已经开发了一种快速灵敏的超高效液相色谱-串联质谱法，用于分析大鼠血浆和脑脊髓液（CSF）中的三种药物。该测定是基于对100 µL样品的液-液萃取。两种类型的样品中的QP，QPOH和QPND方法均得到验证。 QP，QPOH和QPND的血浆检出限（LOD）分别为0.02、0.01和0.02 ng mL -1 ；在CSF样品中，分别为0.02、0.01和0.01 ng mL -1 。通过分析大鼠血浆和脑脊液中QP及其两种活性代谢物的药代动力学和CSF分布特性，证明了该方法的实用性。

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