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首页> 外文期刊>Chromatographia >Application of Native and Hydroxypropyl-Substituted β-Cyclodextrin Bonded Silica Gel as Stationary Phases for High Performance Liquid Chromatography
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Application of Native and Hydroxypropyl-Substituted β-Cyclodextrin Bonded Silica Gel as Stationary Phases for High Performance Liquid Chromatography

机译：天然和羟丙基取代的β-环糊精键合硅胶作为固定相在高效液相色谱中的应用

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摘要

Two chiral stationary phases for high-performance liquid chromatography (HPLC) have been synthesized by grafting native and 2-hydroxypropyl-β-cyclodextrin onto silica gel by a previously described method. They were tested under reversed-phase conditions. These two materials enable separation of the enantiomers of a variety of drugs (benzodiazepine anxiolytics, arylpropionic acids, anti-inflammatory and anticoagulant agents) and herbicides (aryloxyphenoxypropionic esters). Both chiral stationary phases enabled good chiral recognition in reversed-phase mode. The effects of the nature and composition of the mobile phase, of compound structure (mechanisms of chiral discrimination), and of flow-rate were studied.
机译：通过使用前述方法将天然和2-羟丙基-β-环糊精接枝到硅胶上，已经合成了用于高效液相色谱（HPLC）的两个手性固定相。它们在反相条件下进行了测试。这两种材料能够分离多种药物（苯二氮杂类抗焦虑药，芳基丙酸，消炎药和抗凝剂）和除草剂（芳氧基苯氧基丙酸酯）的对映异构体。两个手性固定相都能在反相模式下实现良好的手性识别。研究了流动相的性质和组成，化合物结构（手性鉴别机理）和流速的影响。

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