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首页> 外文期刊>Clinical Infectious Diseases >The Emerging Crisis of Drug‐Resistant Tuberculosis in South Africa: Lessons from New York City
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The Emerging Crisis of Drug‐Resistant Tuberculosis in South Africa: Lessons from New York City

机译：南非新出现的耐药结核病危机：纽约市的教训

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摘要

Multidrug‐resistant tuberculosis and extensively drug‐resistant tuberculosis have emerged as important infections in South Africa among patients infected with human immunodeficiency virus (HIV). In the face of this new epidemic, South Africa must rededicate itself to the task of tuberculosis control and treatment with a rapid, multifaceted approach. Priorities include expansion of second‐line treatment capacity, investment in clinical laboratories, a system to ensure supervised treatment for all patients, and enhancement of infection control procedures. In New York City, where drug‐resistant tuberculosis emerged 2 decades ago—also in the context of a large HIV‐infected population and an underfunded public health infrastructure—similar steps were successful in leading to the rapid decrease in rates of drug resistance among tuberculosis isolates. With refinements based on local resource constraints, urgent measures could potentially arrest the alarming increase in multidrug‐resistant and extensively drug‐resistant tuberculosis cases in South Africa. Unlike many countries in sub‐Saharan Africa, South Africa has the capacity to mount a rapid and large‐scale response before drug‐resistant tuberculosis envelops a much larger and far poorer region.
机译：在南非，在感染人类免疫缺陷病毒（HIV）的患者中，耐多药结核病和广泛耐药性结核病已成为重要的感染。面对这种新的流行病，南非必须以快速，多方面的方式重新致力于结核病的控制和治疗。优先事项包括扩大二线治疗能力，对临床实验室进行投资，确保对所有患者进行监督治疗的系统以及增强感染控制程序。在20年前在纽约市出现耐药结核病的地方-也是在大量HIV感染人群和公共卫生基础设施资金不足的情况下-采取了类似的步骤成功地导致了结核病患者耐药率的迅速下降隔离株。通过根据当地资源的限制进行改进，紧急措施可能会阻止南非多药耐药和广泛耐药结核病例的惊人增长。与撒哈拉以南非洲的许多国家不同，南非有能力在耐药性结核病笼罩更大，更贫穷的地区之前迅速做出大规模反应。

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