Anti-Cancer Natural Product Library from Traditional Chinese Medicine

Thomas Efferth V. Badirenaath Konkimalla

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Anti-Cancer Natural Product Library from Traditional Chinese Medicine

机译：中药抗癌天然产物库

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The cure rates in cancer chemotherapy are affected by the development of drug resistance and severe side effects.nDue to these limitations, there is an urgent need for improved therapeutics. Bioactive compounds from medicinalnplants represent a valuable resource for novel anticancer drugs. To gain a systematic approach, we established a library ofn531 cytotoxic natural products derived from traditional Chinese medicine. Cellular and pharmacogenomic profiling wasnperformed for the 10 most cytotoxic natural products. One of these compounds, helebrin, was analyzed in more detail.nThe IC50 values for hellebrin of 60 NCI cell lines were associated with the microarray-based expression of 9,706 genes.nBy hierarchical cluster analyses, candidate genes were identified which significantly predicted sensitivity or resistance ofncell lines to hellebrin.

机译：癌症化疗的治愈率受耐药性和严重副作用的影响。由于这些限制，迫切需要改进治疗方法。来自药用植物的生物活性化合物代表了新型抗癌药物的宝贵资源。为了获得系统的方法，我们建立了由中药衍生的n531种细胞毒性天然产物的文库。对10种最具细胞毒性的天然产物进行了细胞和药物基因组分析。其中一种化合物helebrin进行了更详细的分析.n 60种NCI细胞株的地狱霉素的IC50值与基于芯片的9,706个基因的表达有关。 Ofncell系去甲蝶呤。

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《Combinatorial Chemistry & High Throughput Screening》 |2008年第1期|p.7-15|共9页
作者
Thomas Efferth V. Badirenaath Konkimalla;
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作者单位

German Cancer Research Center, Pharmaceutical Biology (C015), D-69120, Heidelberg, Germay;

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正文语种 eng
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关键词
Cancer, chemotherapy, natural products, molecular pharmacology, phytochemistry, pharmacognosy, pharmacogenomics; traditional Chinese medicine.;

机译：癌症;化学疗法;天然产物;分子药理学;植物化学;生药学;药物基因组学;中药。;

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1. Anti-cancer natural product library from traditional chinese medicine. [J] . Konkimalla VB, Efferth T Combinatorial chemistry & high throughput screening . 2008,第1期

机译：来自中药的抗癌天然产物库。
2. HIGHLIGHTS FROM THE INTERNATIONAL CONFERENCE ON NEW DEVELOPMENTS IN DRUG DISCOVERY FROM NATURAL PRODUCTS AND TRADITIONAL MEDICINESNATURAL PRODUCTS AND TRADITIONAL MEDICINES: OLD KEYS FOR NEWER PATHOLOGIES [J] . A. Kuhad, K. Chopra Drugs of the Future . 2009,第7期

机译：天然产物和传统药物的药物发现新进展国际会议的亮点天然产物和传统药物：新型病态的旧钥匙
3. Drug-likeness analysis of traditional Chinese medicines: 2. Characterization of scaffold architectures for drug-like compounds, non-drug-like compounds, and natural compounds from traditional Chinese medicines [J] . Sheng Tian, Youyong Li, Junmei Wang, Journal of Cheminformatics . 2013,第S1期

机译：中药的类药物分析：2.表征中药类药物，非类药物和天然化合物的支架结构
4. A Novel Strategy for the Discovery and Characterization of New Natural Products from Traditional Chinese Medicine by Using Benchtop Orbitrap Mass Spectrometer [C] . Chen Li, Jian Qin, Yi Zhang, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：使用BENCHTOP ORBITRAP质谱仪发现和鉴定来自中药新天然产物的新策略
5. A convergent and modular synthesis of dienyl and diynyl isobutylamide natural products from Echinacea and Spilanthes herbal medicines. [D] . Miller, Gabriel A. 2007

机译：紫锥菊和Spilanthes草药的二烯基和二炔基异丁酰胺天然产物的聚合和模块化合成。
6. Drug-likeness analysis of traditional Chinese medicines: 2. Characterization of scaffold architectures for drug-like compounds non-drug-like compounds and natural compounds from traditional Chinese medicines [O] . Sheng Tian, Youyong Li, Junmei Wang, 2013

机译：中药的类药物分析：2.表征中药类药物非类药物和天然化合物的支架结构
7. Drug-likeness analysis of traditional Chinese medicines: 2. Characterization of scaffold architectures for drug-like compounds, non-drug-like compounds, and natural compounds from traditional Chinese medicines [O] . Tian Sheng, Li Youyong, Wang Junmei, 2013

机译：中药的类药物分析：2.表征中药类药物，非类药物和天然化合物的支架结构

Anti-Cancer Natural Product Library from Traditional Chinese Medicine

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