Defensins and Other Antimicrobial Peptides: A Historical Perspective and an Update

Tomas Ganz

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Defensins and Other Antimicrobial Peptides: A Historical Perspective and an Update

机译：防御素和其他抗菌肽：历史的观点和更新。

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Antimicrobial peptides are effectors of innate immunity in phagocytes, body fluids and epithelia. Innmammals, defensins, peptides with a characteristic six-cysteine framework, are particularly abundant and widelyndistributed in various animal species and tissues. The first part of this review provides a historical overview ofnthe ideas that led to the current state-of-the-art in antimicrobial peptides, and the second part is an update onnmammalian defensins and their role in host defense to infections.

机译：抗菌肽是吞噬细胞，体液和上皮细胞先天免疫的效应子。 Innmammals，防御素，具有特征性的半胱氨酸构架的肽特别丰富，并且广泛分布在各种动物物种和组织中。这篇综述的第一部分提供了导致目前抗菌肽最新技术发展的思想的历史综述，第二部分是对纳米防御素及其在感染宿主防御中的作用的更新。

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《Combinatorial Chemistry & High Throughput Screening》 |2005年第3期|p.209-217|共9页
作者
Tomas Ganz;
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作者单位

Departments of Medicine and Pathology, David Geffen School of Medicine, University of California, Los Angeles,Los Angeles, CA 90095-1690, USA;

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正文语种 eng
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History, membrane interactions, peptide structure.;

机译：历史;膜相互作用;肽结构。;

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1. Defensins and other antimicrobial peptides: a historical perspective and an update. [J] . Ganz T Combinatorial chemistry & high throughput screening . 2005,第3期

机译：防御素和其他抗菌肽：历史观点和最新进展。
2. Silencing of Apis mellifera dorsalApis mellifera dorsal genes reveals their role in expression of the antimicrobial peptide defensin‐1defensin‐1 [J] . Louren?o A. P., Florecki M. M., Sim?es Z. L. P., Insect Molecular Biology . 2018,第5期

机译：Apis mellifera dorsalapis mellifera背部基因的沉默揭示了它们在抗微生物肽防御素-1defensin-1的表达中的作用
3. A Hybrid Cationic Peptide Composed of Human beta-Defensin-1 and Humanized theta-Defensin Sequences Exhibits Salt-Resistant Antimicrobial Activity [J] . Olli Sudar, Nagaraj Ramakrishnan, Motukupally Swapna R. Antimicrobial agents and chemotherapy. . 2015,第1期

机译：由人β-防御素-1和人源化的theta-防御素序列组成的杂化阳离子肽表现出耐盐的抗菌活性。
4. Surface Plasmon Resonance Analysis of Beetle Defensin-Derived Antimicrobial Peptide-Membrane Interactions [C] . Jun Ishibashi, Ai Asaoka, Takashi Iwasaki American Peptide Symposium . 2013

机译：甲虫防御素衍生抗微生物肽 - 膜相互作用的表面等离子体共振分析
5. Structure-function studies of defensins and tryptophan-rich antimicrobial peptides. [D] . Schibli, David John. 2003

机译：防御素和富含色氨酸的抗菌肽的结构功能研究。
6. From amino acids polymers antimicrobial peptides and histones to their possible role in the pathogenesis of septic shock: a historical perspective [O] . Isaac Ginsburg, Peter Vernon van Heerden, Erez Koren 2017

机译：从氨基酸聚合物抗菌肽和组蛋白到其在败血性休克发病机理中的可能作用：历史观点
7. A Hybrid Cationic Peptide Composed of Human β-Defensin-1 and Humanized θ-Defensin Sequences Exhibits Salt-Resistant Antimicrobial Activity [O] . Sudar Olli, Ramakrishnan Nagaraj, Swapna R. Motukupally 2014

机译：由人β-防御素-1和人源化θ-防御素序列组成的杂交阳离子肽表现出耐盐性抗微生物活性

Defensins and Other Antimicrobial Peptides: A Historical Perspective and an Update

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