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Developing Soluble Polymers for High-Throughput Synthetic Chemistry

机译:开发用于高通量合成化学的可溶性聚合物

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摘要

Soluble polymers have emerged as viable alternatives to resin supports across the broad spectrum of high-throughput organic chemistry. As the application of these supports become more widespread, issues such as broad-spectrum solubility and loading are becoming limiting factors and therefore new polymers are required to overcome such limitations. This article details the approach made within our group to new soluble polymer supports and specifically focuses on parallel libraries of block copolymers, de novo poly(styrene-cochloromethylstyrene), PEG-‘stealth’ stars, and substituted poly(norbornylene)s.
机译:在广泛的高通量有机化学领域中,可溶性聚合物已成为树脂载体的可行替代品。随着这些载体的应用变得越来越广泛,诸如广谱溶解度和负载的问题正成为限制因素,因此需要新的聚合物来克服这些限制。本文详细介绍了我们小组中针对新型可溶性聚合物载体的方法,并特别关注了嵌段共聚物,从头开始的聚(苯乙烯-氯甲基苯乙烯),PEG-“隐形”星和取代的聚降冰片烯的平行库。

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