The Use of a Supported Base and Strong Cation Exchange (SCX) Chromatography to Prepare a Variety of Structurally-Diverse Molecular Libraries Prepared by Solution-Phase Methods

M. G. Organ C. E. Dixon D. Mayhew D. J. Parks E. A. Arvanitis

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The Use of a Supported Base and Strong Cation Exchange (SCX) Chromatography to Prepare a Variety of Structurally-Diverse Molecular Libraries Prepared by Solution-Phase Methods

机译：使用支持的碱和强阳离子交换（SCX）色谱法制备通过溶液相方法制备的各种结构多样的分子库

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The preparation of molecular libraries of aminomethylbiaryls, allylic amines, and ethanolamines using solution-phase methodology is described. In particular, the use of a solid-supported base reagent (PTBD resin) and strong cation exchange(SCX) resin to effect ‘catch and release’ purification across these diverse libraries is highlighted.

机译：描述了使用溶液相方法制备氨基甲基联芳基，烯丙基胺和乙醇胺的分子库。特别要强调的是，使用固体支持的基础试剂（PTBD树脂）和强阳离子交换（SCX）树脂在这些不同的文库中实现“捕获和释放”纯化。

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来源
《Combinatorial Chemistry & High Throughput Screening》 |2002年第3期|p.211-218|共8页
作者
M. G. Organ C. E. Dixon D. Mayhew D. J. Parks E. A. Arvanitis;
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作者单位

Department of Chemistry,York University, 4700 Keele Street, Toronto, Ontario, Canada M3J 1P3,;

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正文语种 eng
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关键词
molecular library, solution phase method, ptbd resin, scx;

机译：分子库;溶液相法;ptbd树脂;scx;

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1. The use of a supported base and strong cation exchange (SCX) chromatography to prepare a variety of structurally-diverse molecular libraries prepared by solution-phase methods. [J] . Organ MG, Dixon CE, Mayhew D, Combinatorial chemistry & high throughput screening . 2002,第3期

机译：使用支持的碱和强阳离子交换（SCX）色谱来制备通过溶液相方法制备的各种结构多样的分子库。
2. Strong cation exchange (SCX) based analytical methods for the targeted analysis of protein post-translational modifications [J] . Mohammed Shabaz, Heck Albert Jr Current opinion in biotechnology . 2011,第1期

机译：基于强阳离子交换（SCX）的分析方法，用于蛋白质翻译后修饰的靶向分析
3. Combinatorial use of electrostatic repulsion-hydrophilic interaction chromatography (ERLIC) and strong cation exchange (SCX) chromatography for in-depth phosphoproteome analysis [J] . Zarei M., Sprenger A., Gretzmeier C., Journal of proteome research . 2012,第8期

机译：结合使用静电排斥-亲水相互作用色谱（ERLIC）和强阳离子交换（SCX）色谱进行深入的磷酸化蛋白质组分析
4. Dimetal Phosphate Ester Stabilization and Strong-Cation Exchange Chromatography (DIMPES-SCX): A Novel Approach for Phosphopeptide Enrichment [C] . Thiago Verano-Braga, Simon Svane, Christine J. McKenzie, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：二次磷酸酯稳定和强阳离子交换色谱（DiMPES-SCX）：一种新的磷酸富集方法
5. Synthesis of superficially porous silica supports and the investigation of strong cation exchange in ultra-high pressure liquid chromatography. [D] . Sousa, Jason Carlos. 2004

机译：表层多孔二氧化硅载体的合成及超高压液相色谱中强阳离子交换的研究。
6. High pH reversed-phase chromatography with fraction concatenation as an alternative to strong-cation exchange chromatography for two-dimensional proteomic analysis [O] . Feng Yang, Yufeng Shen, David G. Camp II, -1

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The Use of a Supported Base and Strong Cation Exchange (SCX) Chromatography to Prepare a Variety of Structurally-Diverse Molecular Libraries Prepared by Solution-Phase Methods

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