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A multiphysics model for radiofrequency activation of soft hydrated tissues

机译：软水合组织射频激活的多物理场模型

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摘要

A multi-physics model has been developed to investigate the effects of cellular level mechanisms on the electro-thermo-mechanical response of hydrated soft tissues with radiofrequency (RF) activation. A micromechanical model generates an equation of state (EOS) that provides the additional pressure arising from evaporation of intra-and extracellular water as well as temperature to the continuum level thermo-mechanical model. A level set method is used to capture the interfacial evolution of tissue damage with the level set evolution equation derived from the second law of thermodynamics, which is consistent with Griffith's fracture evolution criterion. The discretized equations are solved simultaneously using a Krylov subspace based iterative solver (GMRES) with block preconditioning that effectively deflates the spectrum of the system matrix, resulting in exponential convergence of the Arnoldi iterations. Example problems, including experimental validation, illustrate the computational accuracy and efficiency of the technique. (C) 2018 Elsevier B.V. All rights reserved.
机译：已经开发了一个多物理场模型来研究细胞水平机制对具有射频（RF）激活的水合软组织的电热机械响应的影响。一个微力学模型会生成状态方程（EOS），该方程提供由内部和细胞外水的蒸发以及温度引起的附加压力，从而达到连续水平的热力学模型。使用水平集方法来捕获组织损伤的界面演化，并使用从热力学第二定律推导出的水平集演化方程，该方程与格里菲斯的骨折演化标准相一致。使用具有块预处理的基于Krylov子空间的迭代求解器（GMRES）同时求解离散方程，可以有效地平化系统矩阵的频谱，从而实现Arnoldi迭代的指数收敛。示例问题（包括实验验证）说明了该技术的计算准确性和效率。 （C）2018 Elsevier B.V.保留所有权利。

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