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首页> 外文期刊>Computer methods in biomechanics and biomedical engineering >Modelling the early phases of bone regeneration around an endosseous oral implant
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Modelling the early phases of bone regeneration around an endosseous oral implant

机译：模拟骨内口腔植入物周围骨再生的早期阶段

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摘要

The objective of this study was to see whether a mathematical model of fracture healing was able to mimic bone formation around an unloaded screw-shaped titanium implant as it is well-believed that both processes exhibit many biological similarities. This model describes the spatio-temporal evolution of cellular activities, ranging from mesenchymal stem cell migration, proliferation, differentiation to bone formation, which are initiated and regulated by the growth factors present at the peri-implant site. For the simulations, a finite volume code was used and adequate initial and boundary conditions were applied. Two sets of analyses have been performed, in which either initial and boundary condition or model parameter values were changed with respect to the fracture healing model parameter values. For a number of combinations, the spatio-temporal evolution of bone density was well-predicted. However reducing cell proliferation rate and increasing osteoblast differentiation and osteogenic growth factor synthesis rates, the simulation results were in agreement with the experimental data.
机译：这项研究的目的是观察骨折愈合的数学模型是否能够模拟未加载的螺丝形钛植入物周围的骨形成，因为人们认为这两个过程都显示出许多生物学相似性。该模型描述了细胞活动的时空演变，范围从间充质干细胞迁移，增殖，分化到骨形成，这些活动是由种植体周围部位的生长因子引发和调节的。对于模拟，使用了有限体积代码，并应用了适当的初始条件和边界条件。已经进行了两组分析，其中相对于骨折愈合模型参数值改变了初始条件和边界条件或模型参数值。对于许多组合，可以很好地预测骨密度的时空演变。然而，降低细胞增殖速率并增加成骨细胞分化和成骨生长因子合成速率，模拟结果与实验数据一致。

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    N. Amor; L. Geris; J. Vander Sloten; H. Van Oosterwyck;

  • 作者单位

    Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, Katholieke Universiteit Leuven (K.U.L.), Leuven, Belgium;

    Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, Katholieke Universiteit Leuven (K.U.L.), Leuven, Belgium;

    Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, Katholieke Universiteit Leuven (K.U.L.), Leuven, Belgium;

    Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, Katholieke Universiteit Leuven (K.U.L.), Leuven, Belgium;

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  • 正文语种 eng
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  • 关键词

    mathematical model; numerical simulation; bone regeneration; oral implant;

    机译：数学模型;数值模拟骨再生;口腔植入物;

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