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Molecular interaction between mercury and selenium in neurotoxicity

机译：汞和硒之间的分子相互作用对神经毒性的影响

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摘要

Mercury (Hg) is an environmental toxicant being present in the environment as elemental Hg (Hg), inorganic and organic Hg compounds. The nervous system is supposed to be the key target for Hg toxicity. Research indicates that selenium (Se) may be used as a protective agent against Hg neurotoxicity. Therefore, the aim of this review is to examine new implications of the molecular biology of Hg neurotoxicity, and specifically to focus on the influence of Se compounds and interfering thiols on Hg neurotoxicity at the molecular level. Mercury and Se form stable coordination compounds, and Hg species are characterized by higher affinity to selenol groups as compared to thiol groups. Therefore, Se-containing molecules are targets for Hg binding that may at least partially mediate the biological outcome of Hg-Se interaction. Molecular interaction between these elements also involves mutual interaction between Hg and various selenoproteins. Experimental data demonstrate that Se treatment modifies brain Hg retention, modulates neurotoxicity and oxidative stress in the nervous tissue of animals. Human data also indicate that molecular interaction between Hg and Se may have a significant influence on neurodevelopment, brain functioning, and neurodegeneration. It is hypothesized that the effectiveness of Se protection against Hg neurotoxicity may be determined by the dose of elements as well as their particular chemical forms. Further studies are required to estimate the intimate mechanisms of Hg and Se interaction in vivo. (C) 2016 Elsevier B.V. All rights reserved.
机译：汞（Hg）是一种环境毒物，以元素汞（Hg），无机和有机汞化合物的形式存在于环境中。神经系统被认为是汞毒性的主要靶标。研究表明，硒（Se）可用作抗Hg神经毒性的保护剂。因此，本综述的目的是研究汞神经毒性分子生物学的新含义，特别是在分子水平上重点研究硒化合物和干扰硫醇对汞神经毒性的影响。汞和硒形成稳定的配位化合物，并且与硫醇基相比，汞物种的特征是对硒醇基团的亲和力更高。因此，含硒分子是汞结合的靶标，可以至少部分介导汞-硒相互作用的生物学结果。这些元素之间的分子相互作用还涉及汞与各种硒蛋白之间的相互作用。实验数据表明，硒治疗可改善动物体内神经汞的滞留，调节神经毒性和氧化应激。人体数据还表明，汞和硒之间的分子相互作用可能对神经发育，大脑功能和神经退行性变有重大影响。假设Se对Hg神经毒性的保护作用的有效性可以由元素的剂量及其特定的化学形式决定。需要进一步的研究来估计体内汞和硒相互作用的密切机制。 （C）2016 Elsevier B.V.保留所有权利。

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  • 来源
    《Coordination chemistry reviews》 |2017年第2期|30-37|共8页
  • 作者

    Bjorklund Geir; Aaseth Jan; Ajsuvakova Olga P.; Nikonorov Alexandr A.; Skalny Anatoly V.; Skalnaya Margarita G.; Tinkov Alexey A.;

  • 作者单位

    Council Nutr & Environm Med, Toften 24, N-8610 Mo I Rana, Norway;

    Hedmark Univ Appl Sci, Dept Publ Hlth, Elverum, Norway|Innlandet Hosp Trust, Res Dept, Brumunddal, Norway;

    Orenburg State Pedag Univ, Orenburg, Russia;

    Russian Soc Trace Elem Med, Moscow, Russia;

    Orenburg State Univ, Orenburg, Russia|All Russian Res Inst Med & Aromat Plants, Moscow, Russia|Yaroslavl State Univ, Yaroslavl, Russia|RUDN Univ, Moscow, Russia;

    RUDN Univ, Moscow, Russia;

    Orenburg State Univ, Orenburg, Russia|Yaroslavl State Univ, Yaroslavl, Russia|RUDN Univ, Moscow, Russia|Orenburg State Med Univ, Orenburg, Russia;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Mercury; Selenium; Brain; Selenoproteins; Glutathione peroxidase;

    机译：汞;硒;脑;硒蛋白;谷胱甘肽过氧化物酶;

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