Application of 1,2,4-triazolo[1,5-a]pyrimidines for the design of coordination compounds with interesting structures and new biological properties

Lakomska Iwona; Fandzloch Marzena

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Application of 1,2,4-triazolo[1,5-a]pyrimidines for the design of coordination compounds with interesting structures and new biological properties

机译：1,2,4-三唑并[1,5-a]嘧啶在设计具有有趣结构和新生物学特性的配位化合物中的应用

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This article reviews investigations conducted over the last 15 years that aimed to develop coordination compounds with 1,2,4-triazolo[1,5-a]pyrimidines. The rich diversity of this coordination chemistry provides not only interesting structural chemistry but also exciting therapeutic properties. In particular, these compounds have gained increasing attention in medicinal applications, such as anticancer, antiparasitic and antibacterial prodrugs, and most of these coordination compounds are hypothesized to exhibit higher therapeutic potential than the currently available drugs. In addition, possible structure-activity relationships are discussed and outlined. (C) 2016 Elsevier B.V. All rights reserved.

机译：本文回顾了过去15年中旨在开发与1,2,4-三唑并[1,5-a]嘧啶的配位化合物的研究。这种配位化学的丰富多样性不仅提供了令人感兴趣的结构化学，而且还提供了令人兴奋的治疗特性。特别地，这些化合物在医学应用如抗癌，抗寄生虫和抗菌前药中得到越来越多的关注，并且假设这些配位化合物中的大多数显示出比目前可得的药物更高的治疗潜力。另外，讨论并概述了可能的结构-活性关系。（C）2016 Elsevier B.V.保留所有权利。

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来源
《Coordination chemistry reviews》 |2016年第11期|221-241|共21页
作者
Lakomska Iwona; Fandzloch Marzena;
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作者单位

Nicolaus Copernicus Univ Torun, Fac Chem, Bioinorgan Chem Res Grp, Gagarina 7, PL-87100 Torun, Poland;

Nicolaus Copernicus Univ Torun, Fac Chem, Bioinorgan Chem Res Grp, Gagarina 7, PL-87100 Torun, Poland;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种 eng
中图分类
关键词
Triazolopyrimidine; Metal complexes; Biological activity;

机译：三唑并嘧啶;金属配合物;生物学活性;

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1. H-1{N-15} GHMQC study of 5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine and H-1, C-13 and N-15 NMR coordination shifts in Au(III) chloride complexes of 1,2,4-triazolo[1,5-a]pyrimidines [J] . Szlyk E., Pazderski L., Lakomska I., Magnetic Resonance in Chemistry: MRC . 2002,第8期

机译：H-1 {N-15} GHMQC研究5,7-二苯基-1,2,4-三唑并[1,5-a]嘧啶与Au（1）中的H-1，C-13和N-15 NMR配位位移III）1,2,4-三唑并[1,5-a]嘧啶的氯化物络合物
2. One-Pot Synthesis of 6H-Pyrrolo[2,3-e][1,2,4]triazolo-[1,5-a]pyrimidines on the Basis of sigma~H-Adducts of 6-Nitro[1,2,4]-triazolo[1,5-a]pyrimidine with Carbonyl Compounds [J] . E.B.Gorbunov, G.L.Rusinov, R.I.Ishmetova Russian Journal of Organic Chemistry . 2008,第1期

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3. Coordination chemistry of 5,6,7-trimethyl-[1,2,4]triazolo[1,5-a]pyrimidine with first-row transition-metal salts: Synthesis, spectroscopy and single-crystal structures, with counter-anion dependence of the structures [J] . Adriaanse JH, Askes SHC, van Bree Y, Polyhedron: The International Journal for Inorganic and Organometallic Chemistry . 2009,第14期

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4. Germanium coordination compounds - structure, properties, possible applications [C] . Ya I Lepikh, V A Smyntyna, P O Snigur, Sensors and their Applications . 2007

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5. Design, synthesis, and luminescence properties of bridged dimetallic lanthanide coordination compounds. [D] . Moore, Jeremiah D. 2013

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7. Two Different Compounds Formed from Copper(II) tetrafluoridoborate and [1,2,4]triazolo[1,5-a]pyrimidine. Synthesis, Spectroscopy and Single-Crystal Structures [O] . van den Bos, Eelke D., Mutikainen, Ilpo, Turpeinen, Urho, 2010

机译：由四氟硼酸铜（II）和[1,2,4]三唑并[1,5-a]嘧啶形成的两种不同化合物。合成，光谱学和单晶体结构

Application of 1,2,4-triazolo[1,5-a]pyrimidines for the design of coordination compounds with interesting structures and new biological properties

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