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Porphyrin tweezer receptors: Binding studies, conformational properties and applications

机译：卟啉镊子受体：结合研究，构象性质和应用

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摘要

Metallated porphyrins have been widely used as binding sites in covalently linked molecular tweezer receptors. This review describes selected examples of covalently linked porphyrin tweezer receptors extracted from the extensive literature generated in this area during the last 20 years. The binding processes of some porphyrin tweezer receptors with different substrates are discussed on the basis of the stoichiometry of the formed complexes, the magnitudes of their thermodynamic stabilities and the spec-troscopic techniques used in the characterization. The physicochemical properties of the porphyrin units allow the use of a wide variety of techniques to probe the interaction of the tweezer receptors with different guests. The relationship that exists between the magnitude of the binding constant of 1:1 complexes involving ditopically bound ligands and the conformational features of the spacers is assessed in detail. The different strengths of the non-covalent forces, mainly metal-ligand coordination bonds and it-it interactions, involved in the formation of the host-guest complexes of the tweezers are also discussed and some of the relevant applications of molecular tweezers are also presented. In particular, the use of several porphyrin tweezers in the assignment of absolute configuration of chiral organic compounds using exciton-coupling circular dichroism spectroscopy is described. Finally, porphyrin tweezer receptors prepared through self-assembly processes are introduced and their binding properties emphasized.
机译：金属化的卟啉已广泛用作共价连接的分子镊子受体中的结合位点。这篇综述描述了共价连接的卟啉镊子受体的选定实例，这些受体是从过去20年来在该领域产生的大量文献中提取的。根据形成的配合物的化学计量，其热力学稳定性的大小以及用于表征的光谱技术，讨论了一些卟啉镊子受体与不同底物的结合过程。卟啉单元的物理化学性质允许使用多种技术来探查镊子受体与不同客人的相互作用。详细评估了涉及对位结合的配体的1：1配合物的结合常数的大小与间隔基的构象特征之间存在的关系。还讨论了非共价作用力的不同强度，主要涉及金属-配体配位键及其相互作用，这与镊子的主宾复合物的形成有关，并且还介绍了分子镊子的一些相关应用。特别地，描述了使用激子偶联圆二色光谱法在手性有机化合物的绝对构型分配中使用几种卟啉镊子。最后，介绍了通过自组装过程制备的卟啉镊子受体，并强调了它们的结合特性。

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