Anticancer cyclometalated complexes of platinum group metals and gold

Natalia Cutillas; Gorakh S. Yellol; Concepcion de Haro; Consuelo Vicente; Venancio Rodriguez; Jose Ruiz

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Anticancer cyclometalated complexes of platinum group metals and gold

机译：铂族金属和金的抗癌环金属配合物

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The clinical success of cisplatin and its derivatives has had an enormous impact on the discovery of novel metal-based drugs. Extensive studies have focused on the interaction of metal complexes with their potential targets. The array of organometallic compounds with useful anticancer activity has been significantly extended with respect to metals and structures. This review highlights recent exciting results in the field of cyclometalated C-N complexes and C-N-C, C-N-N and C-N-S pincer complexes of platinum, palladium, gold, ruthenium, rhodium, and iridium with potential anticancer properties.

机译：顺铂及其衍生物的临床成功对新型金属基药物的发现产生了巨大影响。广泛的研究集中在金属配合物与其潜在靶标的相互作用上。具有有用的抗癌活性的有机金属化合物的阵列相对于金属和结构已得到显着扩展。这篇综述突出了在环金属化的C-N络合物以及铂，钯，金，钌，铑和铱的C-N-C，C-N-N和C-N-S钳形络合物领域中具有潜在抗癌特性的最新令人兴奋的结果。

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来源
《Coordination chemistry reviews》 |2013年第20期|2784-2797|共14页
作者
Natalia Cutillas; Gorakh S. Yellol; Concepcion de Haro; Consuelo Vicente; Venancio Rodriguez; Jose Ruiz;
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作者单位

Departamento de Quimica Inorganica and Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia and Instituto Murciano de Investigation Biosanitaria (IMIB), E-30071 Murcia, Spain;

Departamento de Quimica Inorganica and Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia and Instituto Murciano de Investigation Biosanitaria (IMIB), E-30071 Murcia, Spain;

Departamento de Quimica Inorganica and Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia and Instituto Murciano de Investigation Biosanitaria (IMIB), E-30071 Murcia, Spain;

Departamento de Quimica Inorganica and Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia and Instituto Murciano de Investigation Biosanitaria (IMIB), E-30071 Murcia, Spain;

Departamento de Quimica Inorganica and Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia and Instituto Murciano de Investigation Biosanitaria (IMIB), E-30071 Murcia, Spain;

Departamento de Quimica Inorganica and Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia and Instituto Murciano de Investigation Biosanitaria (IMIB), E-30071 Murcia, Spain;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种 eng
中图分类
关键词
Medicinal; Cyclometalated; Organometallic; Anticancer; Platinum; Palladium; Gold; Ruthenium; Iridium; Rhodium; Cancer; Cytotoxicity;

机译：药用环金属化有机金属抗癌铂;钯;金;钌;铱;铑;癌症;细胞毒性;

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1. Cyclometalated Iminophosphorane Gold(III) and Platinum(II) Complexes. A Highly Permeable Cationic Platinum(II) Compound with Promising Anticancer Properties [J] . Frik Malgorzata, Fernandez-Gallardo Jacob, Gonzalo Oscar, Journal of Medicinal Chemistry . 2015,第15期

机译：环金属化亚氨基磷烷金（III）和铂（II）配合物。具有良好抗癌性能的高渗透性阳离子铂（II）化合物
2. Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action [J] . Babak Maria V., Pfaffeneder-Kmen Martin, Meier-Menches Samuel M., Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2018,第5期

机译：翻转环状的Bi0吡啶铂复合物作为有效的抗癌剂：辅助配体对行动方式的影响
3. DNA Binding and Anticancer Activity of Novel Cyclometalated Platinum (II) Complexes [J] . Mohammadi Roghayeh, Yousefi Reza, Aseman Marzieh Dadkhah, Anti-cancer agents in medicinal chemistry . 2015,第1期

机译：新型环金属化铂（II）配合物的DNA结合和抗癌活性。
4. Preparation and Characterization of Cyclometalated Iridium and Platinum Complexes Containing Cobaltadithiolene Complexes [C] . Kosuke Terada, Eri Inaba, Tatsuro Nanbu Symposium on Organometallic Chemistry . 2006

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5. Part I. Structural and luminescence properties of gold(I) benzimidazolethiolate complexes. Part II. Cyclometalated platinum(II) coordination compounds as potential chromophores for the photogeneration of hydrogen from water [D] . Schneider, Jacob 2008

机译：第一部分。苯并咪唑硫醇金（I）配合物的结构和发光特性。第二部分环金属化铂（II）配位化合物作为潜在的生色团，可从水中光生氢
6. CyclometalatedIminophosphorane Gold(III) and Platinum(II)Complexes. A Highly Permeable Cationic Platinum(II) Compound withPromising Anticancer Properties [O] . Malgorzata Frik, Jacob Fernández-Gallardo, Oscar Gonzalo, -1

机译：环金属化亚氨基磷烷金（III）和铂（II）复合体。具有高渗透性的阳离子铂（II）化合物具有有前途的抗癌特性
7. A class of luminescent cyclometalated alkynylgold(III) complexes: synthesis, characterization, and electrochemical, photophysical, and computational studies of [Au(C^N^C)(C≡C-R)] (C^N^C = κ(3)C,N,C bis-cyclometalated 2,6-diphenylpyridyl) [O] . Hung, LL, Wong, KMC, Lam, WH, 2007

机译：一类发光的环金属化炔基金（III）配合物：[au（C ^ N ^ C）（C≡CR）]的合成，表征和电化学，光物理和计算研究（C ^ N ^ C =κ（3） C，N，C双环金属化2,6-二苯基吡啶基）

Anticancer cyclometalated complexes of platinum group metals and gold

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