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首页> 外文期刊>Coordination chemistry reviews >Transition metal-catalyzed cyclocarbonylation in organic synthesis
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Transition metal-catalyzed cyclocarbonylation in organic synthesis

机译：有机合成中过渡金属催化的环羰基化

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Cyclocarbonylation reactions proceed mainly by the coupling reactions of carbonylation components with cyclization components having an unsaturated π-electron bond, in the presence of transition metal compounds. The representative reactions are cyclocarbonylation of alkynes by carbon monoxide such as Pauson-Khand reactions, hetero Pauson-Khand reactions, cyclocarbonylation of alkynyl alcohols, cyclocarbonylation of alkynyl amines, cyclocarbonylative alkyne-alkyne coupling reactions, and reductive cyclocarbonylation of alkynes. The other reactions are cyclocarbonylation of alkenes by carbon monoxide such as alkene-alkene coupling reactions, cyclocarbonylation with aldehydes, ketones, amines or imines, cyclocarbonylation of alkenyl alcohols. Carbonylation via cyclometalation, carbonylative ring expansion reactions, cyclocarbonylation by aldehydes, carboxylic acids or carboxylic acid esters are also cyclocarbonylation reactions. These reactions are conveniently used for organic syntheses, especially, for the syntheses of pharmaceutical intermediates.
机译：在过渡金属化合物的存在下，环羰基化反应主要通过羰基化组分与具有不饱和π电子键的环化组分的偶联反应进行。代表性的反应是通过一氧化碳进行的炔烃的环羰基化，例如Pauson-Khand反应，杂Pauson-Khand反应，炔醇的环羰基化，炔基胺的环羰基化，环羰基化炔烃-炔烃偶联反应和炔烃的还原性环羰基化。其他反应是通过一氧化碳的烯烃环羰基化，例如烯烃-烯烃偶联反应，用醛，酮，胺或亚胺的环羰基化，烯基醇的环羰基化。通过环金属化的羰基化，羰基化的环扩环反应，通过醛，羧酸或羧酸酯的环羰基化也是环羰基化反应。这些反应方便地用于有机合成，特别是用于药物中间体的合成。

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