Optimization of cisplatin for the treatment of hormone dependent tumoral diseases Part 1: Use of steroidal ligands

Ronald Gust; Wolfgang Beck; Gerard Jaouen; Helmut Schoenenberger

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Optimization of cisplatin for the treatment of hormone dependent tumoral diseases Part 1: Use of steroidal ligands

机译：顺铂用于治疗激素依赖性肿瘤疾病的优化方法第1部分：类固醇配体的使用

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Platinum complexes such as cisplatin and carboplatin are metal based drugs, which are widely used in cancer chemotherapy. However, in the current therapy of hormone-dependent breast and prostate cancer they are not established. This might be the result of intrinsic and acquired resistance of the tumors during the therapy. Therefore, several attempts were done to design platinum complexes to address these tumors.rnSteroidal and non-steroidal drugs were modified for the coordination to platinum. The mode of action implies a binding to the estrogen receptor, a selective accumulation in the tumor cells and a specific binding to DNA. In part 1 of this review article we describe the use of steroidal ligands to optimize cisplatin for the treatment of hormone dependent tumoral diseases.

机译：铂配合物（例如顺铂和卡铂）是金属基药物，广泛用于癌症化学疗法。然而，在目前的激素依赖性乳腺癌和前列腺癌治疗中，它们尚未建立。这可能是治疗过程中肿瘤固有的和获得性耐药的结果。因此，进行了一些尝试来设计铂配合物以解决这些肿瘤。甾体和非甾体药物被修饰以与铂配合。作用方式意味着与雌激素受体的结合，在肿瘤细胞中的选择性积累以及与DNA的特异性结合。在这篇综述文章的第1部分中，我们描述了使用类固醇配体优化顺铂治疗激素依赖性肿瘤疾病的方法。

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来源
《Coordination chemistry reviews》 |2009年第22期|2742-2759|共18页
作者
Ronald Gust; Wolfgang Beck; Gerard Jaouen; Helmut Schoenenberger;
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作者单位

Institut fuer Pharmazie der, Freie Universitaet Berlin, Koenigin-Luise-Str. 2+4, 14195 Berlin, Germany;

Department Chemie und Biochemie, Ludwig-Maximilians-Universitaet, Butenandtstr. 5-13, 81377 Muenchen, Germany;

Ecole Nationale Superieure de Chimie de Paris, rue Pierre et Marie Curie 11, 75231 Paris, Cedex 05, France;

Institut fuer Pharmazie, Universitaet Regensburg, Universitaetsstr. 31, 93053 Regensburg, Germany;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种 eng
中图分类
关键词
platinum complexes; steroidal carrier ligands; drug design; mode of action;

机译：铂络合物;类固醇载体配体;药物设计;作用方式;

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1. Optimization of cisplatin for the treatment of hormone-dependent tumoral diseases Part 2: Use of non-steroidal ligands [J] . Ronald Gust, Wolfgang Beck, Gerard Jaouen, Coordination chemistry reviews . 2009,第21a22期

机译：顺铂用于治疗激素依赖性肿瘤疾病的优化方法第2部分：非甾体配体的应用
2. Cisplatin enhances the antitumor effect of tumor necrosis factor-related apoptosis-inducing ligand gene therapy via recruitment of the mitochondria-dependent death signaling pathway [J] . S Shamimi-Noori, W-S Yeow, M F Ziauddin, Cancer gene therapy . 2008,第6期

机译：顺铂通过募集线粒体依赖性死亡信号通路增强肿瘤坏死因子相关的凋亡诱导配体基因治疗的抗肿瘤作用
3. Long pentraxin-3 inhibits FGF8b-dependent angiogenesis and growth of steroid hormone-regulated tumors. [J] . Leali D, Alessi P, Coltrini D, Molecular cancer therapeutics . 2011,第9期

机译：长的pentraxin-3抑制FGF8b依赖性血管生成和类固醇激素调节的肿瘤的生长。
4. Mechanisms of Steroid Hormone Actions on Hypothalamic Nerve Cells: Molecular and Biophysical Studies relevant for Hormone-dependent Behaviors [C] . Lee-Ming Kow, Nandini Vasudevan, Nino Devidze, the Conference Hormones and Brain . 2005

机译：丘脑神经细胞类固醇激素作用的机制：对激素依赖行为的分子和生物物理学研究
5. Flavonoids and steroid hormone-dependent cancers. [D] . Rosenberg Zand, Rachel Stacey. 2001

机译：类黄酮和类固醇激素依赖性癌症。
6. Optimization of the First Selective Steroid-11β-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases [O] . Ulrike E. Hille, Christina Zimmer, Jörg Haupenthal, 2011

机译：用于治疗皮质醇依赖疾病的第一种选择性类固醇11β-羟化酶（CYP11B1）抑制剂的优化
7. Cisplatin enhances the antitumor effect of tumor necrosis factor-related apoptosis-inducing ligand gene therapy via recruitment of the mitochondria-dependent death signaling pathway [O] . S Shamimi-Noori, W-S Yeow, M F Ziauddin, 2008

机译：顺铂通过募集线粒体依赖性死导途径增强肿瘤坏死因子相关凋亡诱导配体基因治疗的抗肿瘤效应

Optimization of cisplatin for the treatment of hormone dependent tumoral diseases Part 1: Use of steroidal ligands

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