Platinum(Ⅳ) antitumour compounds: their bioinorganic chemistry

Matthew D. Hall; Trevor W. Hambley

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Platinum(Ⅳ) antitumour compounds: their bioinorganic chemistry

机译：铂（Ⅳ）类抗肿瘤化合物：其生物无机化学

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This article reviews the investigations undertaken into platinum(Ⅳ) antitumour compounds since Barnett Rosenberg first noted the activity of platinum(Ⅳ) complexes. The chemical and pharmacological properties of the drugs are discussed and both the reactions with individual biomolecules, which have received attention and the characterisation of biotransformation products from animal and clinical trials are reviewed. The bioinorganic chemistry of platinum(Ⅳ) complexes has not previously been reviewed, and the purpose here is to provide insight into the requirements for the antitumour activity of platinum(Ⅳ) complexes.

机译：本文回顾了自Barnett Rosenberg首次指出铂（Ⅳ）配合物的活性以来对铂（Ⅳ）抗肿瘤化合物的研究。讨论了药物的化学和药理特性，并与引起关注的单个生物分子的反应以及动物和临床试验中生物转化产物的表征进行了综述。铂（Ⅳ）配合物的生物无机化学尚未进行过综述，目的是提供对铂（Ⅳ）配合物的抗肿瘤活性要求的见解。

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来源
《Coordination chemistry reviews》 |2002年第2期|p.49-67|共19页
作者
Matthew D. Hall; Trevor W. Hambley;
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作者单位

Centre for Heavy Metals Research, School of Chemistry, University of Sydney, Sydney NSW 2006, Australia;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种 eng
中图分类无机化学;
关键词
platinum(Ⅳ); bioinorganic; metabolite; biotransformation;

机译：铂（Ⅳ）;生物无机;代谢产物;生物转化;

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1. Bioinorganic Chemistry: The Study of the Fate of Platinum-Based Antitumour Drugs [J] . Elisabetta Gabano Mauro Ravera Donato Colangelo Domenico Osella Current Chemical Biology . 2007,第3期

机译：生物无机化学：基于铂的抗肿瘤药物的命运研究
2. Differential processing of antitumour-active and antitumour-inactive trans platinum compounds by SKOV-3 ovarian cancer cells. [J] . Boccarelli A, Giordano D, Natile G, Biochemical Pharmacology . 2006,第3期

机译：SKOV-3卵巢癌细胞对抗肿瘤活性和无肿瘤活性的反式铂化合物的差异处理。
3. Ifrared and Raman Spectra of Inorganic and Coordination Compounds. Part A: Theory and Applications in Inorganic Chemistry; Part B:Application in Coordination, Organometallic, and Bioinorganic Chemistry, 5th Edition [J] . Kazuo Nakamoto Journal of Chemical Education . 2000,第9期

机译：无机和配位化合物的Ifrared和拉曼光谱。 A部分：无机化学的理论与应用; B部分：在配位，有机金属和生物无机化学中的应用，第5版
4. Computational Investigations of Bioinorganic Complexes: The Case of Calcium, Gold and Platinum Ions [C] . Roberto Paciotti, Iogann Tolbatov, Alessandro Marrone, International Conference of Computational Methods in Sciences and Engineering . 2019

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5. Coordination chemistry of mu-oxo diiron(III) compounds containing polyimidazole/pyridine ligands: Inorganic and bioinorganic perspectives. [D] . Wang, Jianping. 1997

机译：含聚咪唑/吡啶配体的mu-oxo diiron（III）化合物的配位化学：无机和生物无机观点。
6. Bioinorganic Chemistry Special Feature: New clues for platinum antitumor chemistry: Kinetically controlled metal binding to DNA [O] . Jan Reedijk 2003

机译：生物无机化学的特殊功能：铂抗肿瘤化学的新线索：金属与DNA结合的动力学控制
7. Synthesis and properties of compounds having novel structure containing heavier group 14 elements / Synthesis of the first stable phosphorusbismuth double-bond compound / Synthesis and properties of the first platinum-dichalcogenide complexes (BIOORGANIC CHEMISTRY - Organoelement Chemistry) [O] . TOKITOH Norihiro, NAKAMURA Kaoru, SUGIYAMA Takashi, 2002

机译：包含更重的14族元素的新型结构的化合物的合成和性能/第一个稳定的磷铋双键化合物的合成/第一个铂-二卤化铂配合物的合成和性能（生物有机化学-有机元素化学）

Platinum(Ⅳ) antitumour compounds: their bioinorganic chemistry

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