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首页> 外文期刊>Croatica Chemica Acta >The Effect of a Single Dose of Fumonisin B_1 on Rat Kidney
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The Effect of a Single Dose of Fumonisin B_1 on Rat Kidney

机译：单剂量伏马菌素B_1对大鼠肾脏的影响

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摘要

It is known that exposure to mycotoxin fumonisin B_1 (FB_1) causes apoptosis and increases lipid peroxidation in the kidney of experimental animals. In this study, adult male Wistar rats were given a single dose (5, 50, 500 μg per kg of body mass) by gavage and sacrificed 4, 24 and 48 hours after dosing. The parameters of oxidative stress, sphingolipids, DNA lesions and histo-pathological changes were checked in the kidney of treated and control animals. The metabolism of sphingolipids was significantly affected with the lowest FB_1 dose (sphinganine/sphingosine: 2.53 ± 0.52 vs. control 0.62 ± 0.10), while even the highest dose did not change the parameters of oxidative stress. DNA lesions measured as comet tail length (range (13.6 ± 0.41) )μm to (19.83 ± 1.43) μm) and tail intensity ((0.60 ± 0.16) % to (2.74 + 0.17) %) were FB_1 dose- and time-dependent. Apoptotic cells and mitotic figures were found in the cortical and outer stripe of the medullar part of the kidney.
机译：已知暴露于霉菌毒素伏马菌素B_1（FB_1）会引起实验动物肾脏的凋亡并增加脂质过氧化作用。在这项研究中，成年雄性Wistar大鼠通过管饲法给予单剂量（5、50、500μg/ kg体重），并在给药后4、24和48小时处死。在治疗和对照动物的肾脏中检查氧化应激，鞘脂，DNA损伤和组织病理学变化的参数。最低的FB_1剂量（鞘氨醇/鞘氨醇：2.53±0.52 vs.对照0.62±0.10）显着影响鞘脂的代谢，而即使最高剂量也不能改变氧化应激的参数。 DNA损伤的测量以彗星尾巴长度（范围（13.6±0.41））μm至（19.83±1.43）μm）和尾巴强度（（0.60±0.16）％至（2.74 + 0.17）％）为FB_1剂量和时间依赖性。在肾的髓质部分的皮质和外条纹中发现凋亡细胞和有丝分裂图。

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