...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Alzheimer Research >Autoimmunity in Alzheimer's Disease as Evidenced by Plasma Immunoreactivity Against RAGE and Aβ42: Complication of Diabetes
【24h】

Autoimmunity in Alzheimer's Disease as Evidenced by Plasma Immunoreactivity Against RAGE and Aβ42: Complication of Diabetes

机译：血浆抗RAGE和Aβ42免疫反应性可证明阿尔茨海默氏病的自身免疫：糖尿病的并发症

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Features of autoimmunity have been associated with both Alzheimer's disease (AD) and with diabetes. In both diseases high levels of advanced glycation end products (AGEs) and their receptor (RAGE) have been detected in tissues and in the circulation. In addition high titers of antibodies directed against a RAGE-like peptide occur in the circulation. In this study we report the presence of auto-antibodies directed against RAGE and the cytotoxic amyloid peptide Aβ42 in plasma samples derived from four study groups. Anti-RAGE IgG titers were greatest in the AD-diabetic cohort. They were followed in decreasing order by the AD-non-diabetic cohort, the elderly diabetic cohort, and lastly by the control non-diabetic elderly cohort. The same profile of IgG differences was evident for the anti-Aβ42 titers. When all of the data were combined, there was a strong linear correlation between the RAGE and Aβ42 titers suggesting that the two peptides exist as a tight complex in plasma. Plasma IgG titers were not correlated with cognitive status except that AD and ADdiabetic participants were significantly cognitively impaired relative to the two non-AD groups. There also was no significant correlation between IgG titers and subject age, except that there was a trend for a negative slope for the AD participants and a positive slope for the control participants. In keeping with the human data, we also report that chemicallyinduced diabetes in rats was associated with high levels of AGEs, anti-RAGE-like IgGs, and anti-Aβ42-like IgGs. For non-diabetic rats, there was a clear age-dependency regarding the magnitude of the IgG levels. These data support the concept of an interrelationship between diabetes and AD. For both diseases one underlying contributing factor to cytotoxicity could be the development of an autoimmune response triggered by the presence of AGEs and amyloid peptides.
机译：自身免疫的特征与阿尔茨海默氏病（AD）和糖尿病都有关系。在这两种疾病中，已在组织和循环中检测到高水平的晚期糖基化终产物（AGEs）及其受体（RAGE）。另外，针对RAGE样肽的高滴度的抗体在循环中发生。在这项研究中，我们报道了来自四个研究组的血浆样品中存在针对RAGE的自身抗体和细胞毒性淀粉样肽Aβ42。在AD糖尿病人群中，抗RAGE IgG效价最高。 AD-非糖尿病队列，老年糖尿病队列和对照非糖尿病老年队列以降序排列。对于抗Aβ42滴度，IgG差异的相同特征是明显的。合并所有数据后，RAGE和Aβ42滴度之间存在很强的线性相关性，表明这两种肽在血浆中以紧密的复合物形式存在。血浆IgG滴度与认知状态无关，只是相对于两个非AD组，AD和AD糖尿病患者的认知能力明显受损。 IgG滴度与受试者年龄之间也没有显着相关性，除了AD受试者呈负斜率且对照组受试者呈正斜率的趋势。与人类数据一致，我们还报告说，大鼠的化学性糖尿病与高水平的AGEs，抗RAGE样IgG和抗Aβ42样IgG有关。对于非糖尿病大鼠，IgG水平的大小具有明显的年龄依赖性。这些数据支持糖尿病和AD之间相互关系的概念。对于这两种疾病，造成细胞毒性的一个潜在因素可能是由AGEs和淀粉样蛋白肽的存在引发的自身免疫反应的发展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号