Fusogenic Viral Envelopes as Potent Vehicles for Gene Transfer

Evgeni G. Ponimaskin Michael f.g. Schmidt

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Fusogenic Viral Envelopes as Potent Vehicles for Gene Transfer

机译：融合病毒包膜作为有效的基因转移载体。

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The development of methods for efficiently introducing foreign genes into living cells provides novel tools to investigate intracellular processes at the molecular level. In addition, the development of suitable delivery vehicles for in vivo gene transfer is a prerequisite for clinical application of therapeutic genes. This review will summarize the current status of the development of both viral as well as non-viral vectors for gene therapy. In addition, we also discuss novel gene-delivery vehicles based on viral envelopes containing fusogenic spike proteins originated from different myxoviruses. These recombinant viral envelopes or virosomes could be viewed as hybrid vectors combining both viral and non-viral strategies, and are well suited for a wider application in therapeutic gene and drug delivery.

机译：有效地将外源基因引入活细胞的方法的开发提供了在分子水平上研究细胞内过程的新颖工具。另外，开发用于体内基因转移的合适的递送载体是治疗基因临床应用的先决条件。本文将概述用于基因治疗的病毒和非病毒载体的发展现状。此外，我们还讨论了基于病毒包膜的新型基因传递载体，该病毒包膜包含源自不同黏液病毒的融合性突突蛋白。这些重组病毒包膜或病毒体可以看作是结合了病毒和非病毒策略的杂交载体，非常适合在治疗基因和药物递送中广泛应用。

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来源
《Current Genomics》 |2001年第3期|p.261-267|共7页
作者
Evgeni G. Ponimaskin Michael f.g. Schmidt;
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作者单位

Abteilung Neuro- und Sinnesphysiologie, Physiologisches Institut, Universitat Gottingen, Humboldtallee 23, D-37073 Gottingen, Germany;

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正文语种 eng
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fusogenic viral envelopes, gene transfer, myxoviruses, non-viral gene transfer, liposome-Mediated gene transfer, virosomes;

机译：融合病毒包膜;基因转移;粘液病毒;非病毒基因转移;脂质体介导的基因转移;病毒体;

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专利

1. Sendai-viral HN and F glycoproteins as probes of plasma-membrane protein catabolism in HTC cells. Studies with fusogenic reconstituted Sendai-viral envelopes [J] . E E Billett, I M Hunneyball, R J Mayer, The biochemical journal . 1987,第3期

机译：仙台病毒HN和F糖蛋白作为HTC细胞血浆膜蛋白分解代谢的探针。融合型仙台病毒包膜的研究
2. Generation of highly potent nonviral gene vectors by complexation of lipoplexes and transferrin-bearing fusogenic polymer-modified liposomes in aqueous glucose solution. [J] . Sakaguchi N, Kojima C, Harada A, Biomaterials . 2008,第9期

机译：通过在葡萄糖水溶液中脂质体和带有运铁蛋白的融合型聚合物修饰脂质体的复合，产生高效非病毒基因载体。
3. Generation of highly potent nonviral gene vectors by complexation of lipoplexes and transferrin-bearing fusogenic polymer-modified liposomes in aqueous glucose solution. [J] . Sakaguchi N, Kojima C, Harada A, Biomaterials . 2008,第9期

机译：通过在葡萄糖水溶液中脂质体和带有运铁蛋白的融合型聚合物修饰脂质体的复合，产生高效非病毒基因载体。
4. Development of an Artificial Viral-like Gene Delivery System Multifunctional Envelope-type Nano Device Equipped with Transferrin and a pH-Sensitive Fusogenic Peptide [C] . Kentaro Sasaki, Shinji Chaki, Kentaro Kogure, Annual meeting exposition of the Controlled Release Society . 2005

机译：配备转铁蛋白和pH敏感融合肽的人工病毒样基因传递系统多功能信封型纳米装置的开发。
5. Characterizing the retroviral envelope glycoprotein membrane proximal external region and membrane-spanning domains for their roles in helical alignment, fusogenicity, and incorporation into viral particles. [D] . Salamango, Daniel. 2015

机译：表征逆转录病毒包膜糖蛋白膜近端外部区域和跨膜结构域在螺旋排列，融合和掺入病毒颗粒中的作用。
6. Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. [O] . E Wagner, C Plank, K Zatloukal, 1992

机译：流感病毒血凝素HA-2 N端融合肽通过转铁蛋白-聚赖氨酸-DNA复合物增强基因转移：向合成的病毒样基因转移载体。
7. Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. [O] . Wagner, E, Plank, C, Zatloukal, K, 1992

机译：流感病毒血凝素HA-2 N端融合肽通过转铁蛋白-聚赖氨酸-DNA复合物增强基因转移：向合成的病毒样基因转移载体。

Fusogenic Viral Envelopes as Potent Vehicles for Gene Transfer

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