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首页> 外文期刊>Current Immunology Reviews >The Phenotypic and Metabolic Characteristics of Neutrophils in Normal Pregnancy and Preeclampsia
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The Phenotypic and Metabolic Characteristics of Neutrophils in Normal Pregnancy and Preeclampsia

机译：正常妊娠和先兆子痫中性粒细胞的表型和代谢特征

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In preeclampsia, poor placentation is an important predisposing factor and endothelial damage underlies disease manifestations. Although the processes leading to endothelial damage are not fully understood, the maternal innate immune system, particularly neutrophils, has been identified as key players. In preeclampsia there is evidence of increased neutrophil activation, marked by up-regulation of neutrophil integrin expression, and increased production of the protease elastase and reactive oxygen species. Direct evidence of neutrophil mediated endothelial cell damage is also reported. The placenta may release various factors that stimulate neutrophil activation in response to reduced perfusion due to poor placentation. They include increased production of pro-inflammatory cytokines, oxidative damage products, and syncytiotrophoblast microvesicles. The relationship between neutrophil activation and endothelial damage argues for a role for neutrophils in the pathogenesis of preeclampsia. In this review, we focus on the phenotypic and metabolic characteristics of neutrophils in normal pregnancy and preeclampsia in order to identify the potential cellular and molecular processes that contribute to the maternal endothelial damage seen in preeclampsia.
机译：在先兆子痫中，胎盘不良是重要的诱发因素，内皮损害是疾病表现的基础。尽管尚不完全清楚导致内皮损伤的过程，但母体先天免疫系统，特别是嗜中性粒细胞，已被确定为关键因素。在先兆子痫中，有证据表明嗜中性粒细胞活化增加，以嗜中性粒细胞整联蛋白表达上调为特征，并且蛋白酶弹性蛋白酶和活性氧的产生增加。还报道了中性粒细胞介导的内皮细胞损伤的直接证据。胎盘可能会释放各种因素，以响应由于不良胎盘引起的灌注减少而刺激中性粒细胞活化。它们包括促炎性细胞因子，氧化损伤产物和合体滋养层微泡的增加产量。中性粒细胞活化与内皮损伤之间的关系表明，中性粒细胞在先兆子痫的发病机理中具有重要作用。在这篇综述中，我们着重于正常妊娠和先兆子痫中嗜中性粒细胞的表型和代谢特征，以鉴定导致先兆子痫中母体内皮损伤的潜在细胞和分子过程。

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