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首页> 外文期刊>Current Immunology Reviews >Cosignaling Complexity Gets More Convoluted: The Emerging Importance of the B7-Like Butyrophilin Family of Immune Regulators
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Cosignaling Complexity Gets More Convoluted: The Emerging Importance of the B7-Like Butyrophilin Family of Immune Regulators

机译：信号复杂性变得更加令人费解：免疫调节剂的B7样酪氨酸家族的新兴重要性。

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摘要

Activation of T cells is known to be modulated by positive or negative co-signaling molecules. The B7-familynof costimulatory molecules has received the greatest attention in the past, and intervention in B7-family signaling pathwaysnhas proven to be an efficacious strategy for treating autoimmune diseases in the clinic. In recent months a new familynof molecules has garnered interest -- the butyrophilins -- and early data is suggesting that these butyrophilin and butyrophilin-nlike molecules have the potential for influencing the nature of immune and inflammatory responses. In vitro studiesnhave revealed that butyrophilins, such as butyrophilin-like 2 (BTNL2), can negatively regulate T cell proliferation andncytokine production. Additionally, genetic studies have described polymorphisms in BTNL2 which are reported to be associatednwith disorders such as sarcoidosis, myositis and ulcerative colitis. The potential for interdicting the butyrophilinnpathways highlights potential opportunities for developing new therapeutic strategies for treating autoimmune and inflammatoryndisorders. This review will focus on the emerging information of this new class of regulatory molecules.
机译：已知T细胞的激活受正或负共信号分子调节。过去，B7-家族的共刺激分子受到了最大的关注，在临床上，干预B7-家族的信号传导途径已被证明是治疗自身免疫性疾病的有效策略。近几个月来，一个新的家族分子-酪氨酸-引起了人们的兴趣，早期数据表明，这些酪氨酸和类似酪氨酸的分子具有影响免疫和炎症反应性质的潜力。体外研究表明，酪氨酸蛋白，例如butyrophilin-like 2（BTNL2），可以负面调节T细胞增殖和细胞因子的产生。另外，遗传研究已经描述了BTNL2中的多态性，据报道其与诸如结节病，肌炎和溃疡性结肠炎的疾病有关。阻断嗜丁菌素通路的潜力突显了开发治疗自身免疫和炎性疾病的新治疗策略的潜在机会。这篇综述将集中在这种新型调节分子的新兴信息上。

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