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Host Immune Responses to Aeromonas Virulence Factors

机译：宿主对气单胞菌毒力因子的免疫反应

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Aeromonas species are emerging human pathogens, which produce an array of virulence factors and cause diseases ranging from gastroenteritis to systemic infections. These bacteria can be found in food and water and grow well and produce toxins at refrigeration temperatures, which greatly increase the risk of food poisoning. A detailed understanding of host responses to Aeromonas virulence factors is paramount to developing better treatment strategies. One of the important virulence factors of Aeromonas is the cytotoxic enterotoxin, Act, which induces potent inflammatory responses in host cells and is lethal when injected intravenously into mice. Microarray analyses of Act-treated host cells by our laboratory revealed that Act induced host cell signaling and apoptosis of macrophages and colonic epithelial cells. We furthered showed that Act production is regulated by glucose inhibited division gene A (gidA) and an iron-regulated ferric uptake regulatory (fur) gene. In addition to Act, our laboratory recently discovered new virulence factors/mechanisms, including the plasminogen-activating enzyme enolase and a type III secretion system, which contribute to Aeromonas-associated diseases. Current knowledge concerning host responses to these and other Aeromonas virulence factors is discussed.
机译：气单胞菌物种是新兴的人类病原体，其产生一系列毒力因子，并引起从胃肠炎到全身感染的疾病。这些细菌可以在食物和水中找到，并能很好地生长，并在冷藏温度下产生毒素，这大大增加了食物中毒的风险。对宿主对气单胞菌毒力因子反应的详细了解对于制定更好的治疗策略至关重要。气单胞菌的重要毒力因子之一是细胞毒素肠毒素法，该毒素在宿主细胞中诱导有效的炎症反应，并在静脉内注射给小鼠时具有致命性。我们实验室对Act处理过的宿主细胞进行的微阵列分析表明，Act可以诱导宿主细胞信号传导以及巨噬细胞和结肠上皮细胞的凋亡。我们进一步表明，Act的产生受到葡萄糖抑制分裂基因A（gidA）和铁调节的铁摄取调节（fur）基因的调节。除了Act之外，我们的实验室最近还发现了新的毒力因子/机制，包括纤溶酶原激活酶烯醇酶和III型分泌系统，这些都是导致气单胞菌相关疾病的原因。讨论了有关宿主对这些和其他气单胞菌毒力因子的反应的当前知识。

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