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首页> 外文期刊>Current Immunology Reviews >Activation and Costimulation of Intestinal T Cells: Independent and Collaborative Involvement of CD43, OX40, and Ly-6C
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Activation and Costimulation of Intestinal T Cells: Independent and Collaborative Involvement of CD43, OX40, and Ly-6C

机译：激活和共刺激肠道T细胞：CD43，OX40和Ly-6C的独立和协同参与。

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摘要

T cells are present in large numbers in the epithelial lining of the small and large intestine of humans and mice. Those cells, referred to as intraepithelial lymphocytes (IELs), are critical for maintaining an effective mucosal immune response against the onslaught of enteric infectious agents and intestinal neoplasia. However, because intestinal immunity must by necessity occur rapidly and efficiently, it is concomitantly important that the local intestinal immune response be curtailed so as not to result in conditions that lead to a destructive inflammatory environment as occurs in inflammatory bowel disease (IBD). Although many aspects of the IEL activation process remain to be understood, emerging evidence indicates that costimulatory molecules on IELs are critical for activation and that they hold the key to regulating intestinal immunity across many levels. In this article, the involvement of three IEL costimulatory molecules (CD43, OX40, and Ly-6C) - working independently or in collaboration-will be discussed in the context of immunity and disease in the human and mouse intestine, and the involvement of those in sustaining the IELs in a uniquely precarious but effective state of activation readiness will be explored.
机译：T细胞大量存在于人和小鼠小肠和大肠的上皮内膜中。这些细胞被称为上皮内淋巴细胞（IEL），对于维持有效的粘膜免疫反应以抵抗肠传染病和肠肿瘤形成至关重要。但是，由于必须快速有效地进行肠道免疫，因此重要的是应减少局部肠道免疫反应，以免导致炎症性肠病（IBD）引起破坏性炎症环境的状况。尽管IEL激活过程的许多方面尚待理解，但新兴证据表明，IEL上的共刺激分子对于激活至关重要，并且它们在许多层面上都具有调节肠道免疫力的关键。在本文中，将在人类和小鼠肠道的免疫力和疾病的背景下讨论三种独立或协同工作的IEL共刺激分子（CD43，OX40和Ly-6C）的参与，以及这些参与分子的参与在维持IEL处于不稳定状态但有效的激活准备状态的过程中，将进行探索。

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