Myelin Sheaths and Autoimmune Response Induced by Myelin Proteins and Alphaviruses. I. Physicochemical Background

Jan Sedzik

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Myelin Sheaths and Autoimmune Response Induced by Myelin Proteins and Alphaviruses. I. Physicochemical Background

机译：髓鞘和髓磷脂蛋白和甲病毒引起的自身免疫反应。一，理化背景

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Myelin proteins of the central and peripheral nervous system range from very hydrophilic to extremely hydrophobic proteins. Their biological function and involvement in various clinically defined neurological diseases are well documented. In this review the myelin proteins will be compared with proteins of alphaviruses with emphasis on Semliki Forest Virus (strain pSP6-SFV4), to elucidate better the multiple function and the potential role in several neurological diseases.nnThe main purpose of this review is to assist neuroscientists, neurochemists, neurologists, and other interested scientists in developing a better understanding on the information relating to myelin proteins referred in autoimmune diseases. Therefore, this review is focused on simple physiochemical background of proteins and structural aspect, which may be involved in autoimmunity. It is very unusual that few different a.a. sequences (epitops) induce indeed the same autoimmune reaction.

机译：中枢和外周神经系统的髓磷脂蛋白的范围从非常亲水的蛋白质到非常疏水的蛋白质。它们的生物学功能和参与各种临床定义的神经系统疾病的文献已得到充分证明。在这篇综述中，将髓磷脂蛋白与重点突出于Semliki森林病毒（pSP6-SFV4株）的α病毒蛋白进行比较，以更好地阐明其多功能性和在几种神经系统疾病中的潜在作用。神经科学家，神经化学家，神经学家和其他感兴趣的科学家，以便更好地了解与自身免疫性疾病中涉及的髓磷脂蛋白有关的信息。因此，本综述着眼于蛋白质的简单生理化学背景和结构方面，这可能与自身免疫有关。很少有不同的a.a.序列（表位）确实引起相同的自身免疫反应。

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《Current Medicinal Chemistry》 |2008年第19期|p.1899-1910|共12页
作者
Jan Sedzik;
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作者单位

Karolinska Institutet, NVS, Div. of Neurodegeneration and Neuroinflammation, NOVUM pl 5, 141 86 Stockholm, Sweden.;

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正文语种 eng
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Myelin, proteins, autoimmune reaction, Semliki Forest Virus, neurodegeneration, molecular mimicry;

机译：髓磷脂;蛋白质;自身免疫反应;塞姆利基森林病毒;神经退行性疾病;分子模拟;

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专利

1. Myelin sheaths and autoimmune response induced by myelin proteins and alphaviruses. I. Physicochemical background. [J] . Sedzik J Current medicinal chemistry . 2008,第19期

机译：髓鞘蛋白和髓鞘蛋白和α病毒诱导的自身免疫应答。一，理化背景。
2. Experimental autoimmune encephalomyelitis induced with a combination of myelin basic protein and myelin oligodendrocyte glycoprotein is ameliorated by administration of a single myelin basic protein peptide. [J] . Leadbetter EA, Bourque CR, Devaux B, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1998,第1期

机译：通过施用单一的髓鞘碱性蛋白肽可以改善由髓鞘碱性蛋白和髓鞘少突胶质细胞糖蛋白的组合诱导的实验性自身免疫性脑脊髓炎。
3. Antibody response to myelin oligodendrocyte glycoprotein and myelin basic protein depend on familial background and are partially associated with human leukocyte antigen alleles in multiplex families and sporadic multiple sclerosis. [J] . Lutterotti A, Reindl M, Gassner C, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2002,第1a2期

机译：对髓鞘少突胶质细胞糖蛋白和髓鞘碱性蛋白的抗体应答取决于家族背景，并且与多重家族和偶发性多发性硬化中的人白细胞抗原等位基因部分相关。
4. Design and synthesis of a potent analogue of myelin basic protein MBP_(87-99)Epitope:Inhibition of experimental autoimmune encephalomyelitis(Eae) [C] . George Deraos, Theodore Tselios, Spiros Deraos International Peptide Symposium;European Peptide Symposium . 2005

机译：髓鞘碱性蛋白质MBP_（87-99）表位的有效类似物的设计和合成：抑制实验性自身免疫性脑脊髓炎（EAE）
5. Protection and treatment of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein and expansion of dendritic cells using Flt-3L. [D] . Wardrop, Richard McNeil, III. 2000

机译：通过口服髓磷脂碱性蛋白和使用Flt-3L扩增树突状细胞来保护和治疗实验性自身免疫性脑脊髓炎。
6. Experimental Autoimmune Encephalomyelitis (EAE)-Induced Elevated Expression of the E1 Isoform of Methyl CpG Binding Protein 2 (MeCP2E1): Implications in Multiple Sclerosis (MS)-Induced Neurological Disability and Associated Myelin Damage [O] . Tina Khorshid Ahmad, Ting Zhou, Khaled AlTaweel, 2017

机译：实验性自身免疫性脑脊髓炎（EAE）诱导的甲基CpG结合蛋白2（MeCP2E1）的E1亚型的表达升高：在多发性硬化症（MS）诱导的神经功能障碍和相关的髓鞘损害中的意义
7. A Structurally Available Encephalitogenic Epitope of Myelin Oligodendrocyte Glycoprotein Specifically Induces a Diversified Pathogenic Autoimmune Response [O] . Felix Bischof, Adriaan Bins, Michael Dürr, 2004

机译：髓鞘寡核细胞糖蛋白的结构可用脑发生表位特异性诱导多样化的致病性自身免疫反应
8. Myelin Basic Protein-Messenger RNA (MBP-mRNA) Expression during Triethyltin-Induced Myelin Edema [R] . Veronesi, B., Jones, K., Gupta, S., 1991

机译：髓磷脂碱性蛋白 - 信使RNa（mBp-mRNa）在三乙基锡诱导的髓鞘水肿期间的表达

Myelin Sheaths and Autoimmune Response Induced by Myelin Proteins and Alphaviruses. I. Physicochemical Background

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