Cell cycle kinases in cancer

Marcos Malumbres; Mariano Barbacid

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Cell cycle kinases in cancer

机译：癌症中的细胞周期激酶

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Cell division in mammalian cells is driven by protein kinases that regulate progression through the various phases of the cell cycle. Cyclin-dependent kinases (Cdks) regulate cell cycle commitment, DNA synthesis and the onset of mitosis. Kinases of the Aurora, Polo and Nek families participate in the centrosome cycle and modulate spindle function. Additional kinases such as Bub1, BubR1 and Mps1 regulate the spindle assembly checkpoint. It has been well established that misregulation of Cdks is one of the most frequent alterations in human cancer. Recent evidence indicates that mutations involving mitotic kinases are also linked to tumor development. These findings suggest novel strategies to use cell cycle kinases as targets for therapeutic intervention.

机译：哺乳动物细胞中的细胞分裂是由调节整个细胞周期各个阶段进程的蛋白激酶驱动的。细胞周期蛋白依赖性激酶（Cdks）调节细胞周期承诺，DNA合成和有丝分裂的发作。 Aurora，Polo和Nek家族的激酶参与中心体周期并调节纺锤体功能。其他激酶（例如Bub1，BubR1和Mps1）调节主轴组装检查点。众所周知，Cdks的失调是人类癌症中最常见的改变之一。最近的证据表明，涉及有丝分裂激酶的突变也与肿瘤的发展有关。这些发现表明使用细胞周期激酶作为治疗干预目标的新策略。

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《Current Opinion in Genetics & Development》 |2007年第1期|p.60-65|共6页
作者
Marcos Malumbres; Mariano Barbacid;
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作者单位

Cell Division and Cancer, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas (CNIO), 28029 Madrid, Spain;

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正文语种 eng
中图分类遗传学;
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1. Asiatic Acid,a Triterpene,Induces Apoptosis and Cell Cycle Arrest through Activation of Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways in Human Breast Cancer Cells [J] . Ya-Ling Hsu, Po-Lin Kuo, Liang-Tzung Lin, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2005,第1期

机译：亚洲酸，一种三萜，通过激活人乳腺癌细胞中的细胞外信号调节激酶和p38丝裂原活化的蛋白激酶途径，诱导细胞凋亡和细胞周期阻滞。
2. Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in?human gastric cancer AGS [J] . Chun-Xiu Yuan, Zhi-Wei Zhou, Yin-Xue Yang, Drug Design, Development and Therapy . 2015,第4期

机译：Danusertib是一种有效的泛Aurora激酶和ABL激酶抑制剂，可诱导细胞周期停滞和程序性细胞死亡，并抑制涉及PI3K / Akt / mTOR介导的人胃癌AGS信号传导途径的上皮向间质转化。
3. Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors. [J] . Collins I, Garrett MD Current opinion in pharmacology . 2005,第4期

机译：针对癌症中的细胞分裂周期：CDK和细胞周期检查点激酶抑制剂。
4. Elucidation of Direct Substrates of Abelson Tyrosine Kinase in Cancer Cells Through Multiple Drug Treatments and Sensitiv e Kinase Assay Linked-Phosphoproteomics [C] . Justine Arrington, Liang Xue, W. Andy Tao American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：通过多种药物处理和灵敏剂E激酶测定连接 - 磷蛋白质学通过多种药物治疗癌细胞中Abelson酪氨酸激酶的直接衬底阐明
5. Calcium/calmodulin-dependent kinases participate in the cell cycle regulation and antiapoptotic mechanisms in MCF-7 human breast cancer cells. [D] . Rodriguez-Mora, Oswaldo Giovanny. 2005

机译：钙/钙调蛋白依赖性激酶参与MCF-7人乳腺癌细胞的细胞周期调控和抗凋亡机制。
6. Naturally Occurring Sclareol Diterpene Augments the Chemosensitivity of Human Hela Cervical Cancer Cells by Inducing Mitochondrial Mediated Programmed Cell Death S-Phase Cell Cycle Arrest and Targeting Mitogen-Activated Protein Kinase (MAPK)/Extracellular-Signal-Regulated Kinase (ERK) Signaling Pathway [O] . Wang Li, Zhou Ping, Gao Xuemei, 2020

机译：天然存在的香紫苏二萜通过诱导线粒体介导的程序性细胞死亡S期细胞周期阻滞和靶向丝裂原活化的蛋白激酶（MAPK）/细胞外信号调节激酶（ERK）信号通路来增强人类Hela宫颈癌细胞的化学敏感性。
7. Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase–activated protein kinase 2 in mediating DNA damage–induced cell cycle arrest: implications for cancer therapy [O] . Zhan Xiao, John Xue, Thomas J. Sowin, 2006

机译：检查点激酶1，检查点激酶2和丝裂原激活蛋白激酶激活蛋白激酶2在介导DNA损伤诱导细胞周期骤停中的差异作用：癌症治疗的影响

Cell cycle kinases in cancer

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