mTOR and cancer: reason for dancing at the crossroads?

Thomas GV

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mTOR and cancer: reason for dancing at the crossroads?

机译：mTOR和癌症：在十字路口跳舞的原因？

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Recent successes using Gleevec for the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors have provided proof that strategies to target signal transduction pathways mutated in human cancers can work. However, the application of this strategy to other cancers has been slow. Central to alleviating this impedance is the molecular characterization of the tumors. There is an urgent need to translate basic scientific findings into relevant, clinically applicable molecular diagnostic assays.

机译：使用格列卫（Gleevec）治疗慢性粒细胞性白血病和胃肠道间质瘤的最新成功提供了证明靶向人类癌症中突变的信号转导途径的策略行之有效的证据。但是，该策略在其他癌症中的应用进展缓慢。减轻这种阻抗的关键是肿瘤的分子表征。迫切需要将基础科学发现转化为相关的，可临床应用的分子诊断检测方法。

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《Current Opinion in Genetics & Development》 |2006年第1期|p.78-84|共7页
作者
Thomas GV;
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Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California Los Angeles, A7-149 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095-1732, USA.;

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mTOR and cancer: reason for dancing at the crossroads?

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