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首页> 外文期刊>Current Opinion in Genetics & Development >p63: oncogene or tumor suppressor?
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p63: oncogene or tumor suppressor?

机译：p63：癌基因或抑癌药？

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摘要

p53, the original member of the family of genes now known to include p63 and p73, was first heralded as an oncogene because of its potent transformation capabilities and its robust expression in human tumors. However, it was later discovered that only mutant p53 was oncogenic, and that wild type p53 functioned as a tumor suppressor. Decades later, p63, the newest member of this gene family, is involved in a similar controversy: is p63 an oncogene or a tumor suppressor? Recent progress on understanding the in vivo role of p63 in cancer has focused primarily on investigating its involvement in the tumor-suppressive mechanism of apoptosis, by analyzing mouse models to assess its tumor-suppressive capabilities, and by assessing its expression in human cancers.
机译：p53是现在已知包括p63和p73的基因家族的原始成员，由于其强大的转化能力和在人类肿瘤中的强大表达，首次被宣布为癌基因。然而，后来发现只有突变型p53具有致癌性，而野生型p53却具有抑癌作用。数十年后，该基因家族的最新成员p63参与了类似的争论：p63是癌基因还是抑癌药？在了解p63在癌症中的体内作用方面的最新进展主要集中在研究其参与凋亡的肿瘤抑制机制，通过分析小鼠模型以评估其肿瘤抑制能力以及评估其在人类癌症中的表达。

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