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Cytogenetic and Immunogenetic Analysis of Recurrent Pregnancy Loss in Women

机译：女性反复妊娠流产的细胞遗传学和免疫遗传学分析

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摘要

Karyotyping of 366 couples (732 individuals) with early recurrent pregnancy losses in anamnesis revealed chromosomal anomalies in 4.09% (30 cases)-within them 2.05% carry reciprocal translocations, in 0.82%-Robertsonian translocations, 0.55% carry numerical and structural gonosomal anomalies and in 0.27%-marker chromosome of unknown origin. The risk of early reproductive losses in women after excluding the cytogenetic component increases three fold if SNPs 1082GG, 592CC, 819CC of IL-10 gene and IFN-γ + 874AT or 874AA genotypes are present. ELISA-mediated detection of serum IL-10 and IFN-γ showed a possibly significant increase of IFN-γ in women with the history of early reproductive losses when compared to reproductively healthy women. We are proposing a complex cyto- and immunogenetic investigation in cases of early reproductive losses in women. One of the important issues of reproduction are the immunological mechanisms of pregnancy maintenance, where the disbalance in the genetically determined Th1- and Th2-cytokine levels may be one of the causes of early fetus elimination.
机译：366对夫妇（732个体）的核型分型，发现早期反复流产的失忆导致染色体异常，其中4.09％（30例）-其中2.05％携带易位，0.82％-Robertsonian易位，0.55％携带数字和结构性性染色体异常，在未知来源的0.27％标记染色体中。如果存在IL-10基因的SNP 1082GG，592CC，819CC和IFN-γ+ 874AT或874AA基因型，则排除细胞遗传成分的女性早期生殖损失的风险增加了三倍。 ELISA介导的血清IL-10和IFN-γ检测显示，与生殖健康女性相比，有早期生殖功能减退史的女性中IFN-γ可能显着增加。我们建议对女性早期生殖功能丧失进行复杂的细胞和免疫遗传学研究。繁殖的重要问题之一是维持妊娠的免疫机制，其中遗传确定的Th1和Th2细胞因子水平的失衡可能是胎儿早期消除的原因之一。

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  • 来源
    《Cytology and genetics》 |2014年第4期|238-243|共6页
  • 作者

    D. Zastavna; K. Sosnina; O. Terpylyak; N. Huleyuk; H. Bezkorovayna; M. Mikula; N. Helner;

  • 作者单位

    Institute of Hereditary Pathology of National Academy of Medical Sciences of Ukraine,ul. Lysenko 31a, Lviv, 79000 Ukraine;

    Institute of Hereditary Pathology of National Academy of Medical Sciences of Ukraine,ul. Lysenko 31a, Lviv, 79000 Ukraine;

    Institute of Hereditary Pathology of National Academy of Medical Sciences of Ukraine,ul. Lysenko 31a, Lviv, 79000 Ukraine;

    Institute of Hereditary Pathology of National Academy of Medical Sciences of Ukraine,ul. Lysenko 31a, Lviv, 79000 Ukraine;

    Institute of Hereditary Pathology of National Academy of Medical Sciences of Ukraine,ul. Lysenko 31a, Lviv, 79000 Ukraine;

    Institute of Hereditary Pathology of National Academy of Medical Sciences of Ukraine,ul. Lysenko 31a, Lviv, 79000 Ukraine;

    Institute of Hereditary Pathology of National Academy of Medical Sciences of Ukraine,ul. Lysenko 31a, Lviv, 79000 Ukraine;

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  • 正文语种 eng
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  • 关键词

    recurrent pregnancy loss; chromosomal anomalies; single nucleotide polymorphisms; IL-10 and IFN-γ;

    机译：反复流产;染色体异常;单核苷酸多态性IL-10和IFN-γ;

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