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首页> 外文期刊>Cytology and genetics >Phenomenon of Evolution of Clonal Chromosomal Abnormalities in Childhood Acute Myeloid Leukemia
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Phenomenon of Evolution of Clonal Chromosomal Abnormalities in Childhood Acute Myeloid Leukemia

机译：儿童急性髓性白血病克隆染色体异常演变现象

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An analysis of chromosomal abnormalities in bone-marrow cells was performed in 116 children with diagnoses of acute myeloid leukemia (AML). The frequency of the evolution of clonal chromosomal abnormalities in AM L constituted 42.3%. Quantitative abnormalities of chromosomes 8, 9. and 21, as well as the secondary structural abnormalities in the chromosomal regions 12 p12, 9p22, 9q22, 9q34, 1 1q 14-23, and 6q2, were the most abundant. Quantitative abnormalities were registered in 26.7% cases. The basic mechanism of evolution of the leukemic clone contained trisomy, deletions, and monosomy. The frequency of evolution was seven times higher in the age group of up to 2 years and twofold higher in the age group of up to 5 years. The high frequency of evolution at t(15; 17)(q22;q22) was established, while its absence was revealed at inv(16)(p13q22). Patients with clonal evolution were characterized by the increased frequency of relapses and earlier death before reaching remission, which might be explained by the severe initial state of those patients. The conception of abnormalities in the evolution of the clone was proposed to occur at certain stages as follows: (1) appearance of balanced rearrangements; (2) trisomy occurrence; (3) loss of chromosomal material. The occurrence of an unbalanced genome during evolution possesses advantages in the clonal proliferate activity and may be related to its response to chemotherapy. An identity in abnormal chromosomal structure was revealed as a result of the comparison of karyotypes during diagnostics and during relapse, which could be evidence of the initial induction of some types of evolution of chromosomal abnormalities in leukemic cells in AML children by the chemical agents.
机译：对116名诊断为急性髓细胞性白血病（AML）的儿童进行了骨髓细胞染色体异常的分析。 AM L中克隆染色体异常发生的频率占42.3％。染色体8、9和21的定量异常以及染色体区域12 p12、9p22、9q22、9q34、1 1q 14-23和6q2的二级结构异常最为丰富。数量异常登记在案率为26.7％。白血病克隆进化的基本机制包括三体性，缺失和单体性。在2岁以下的年龄组中，进化的频率高出7倍，在5岁以下的年龄组中，进化的频率高出两倍。建立了在t（15; 17）（q22; q22）处的高进化频率，而在inv（16）（p13q22）处揭示了它的不存在。具有克隆进化的患者的特征是复发频率增加，到达缓解之前更早死亡，这可能由这些患者的严重初始状态来解释。有人提出克隆进化中的异常概念在某些阶段发生如下：（1）出现平衡重排； （2）三体性发生； （3）染色体物质的损失。在进化过程中不平衡基因组的出现在克隆增殖活性方面具有优势，并且可能与其对化学疗法的反应有关。通过诊断和复发期间核型的比较，揭示了异常染色体结构的同一性，这可能是化学试剂对白血病儿童白血病细胞中某些类型的染色体异常进化的初步诱导的证据。

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    《Cytology and genetics》 |2010年第3期|P.160-169|共10页
  • 作者

    S. V. Andreieva; V. D. Drozdova; N. V. Kavardakova;

  • 作者单位

    Institute of Haematology and Transfusiology Academy of Medical Sciences of Ukraine, Kiev, Ukraine;

    rnInstitute of Haematology and Transfusiology Academy of Medical Sciences of Ukraine, Kiev, Ukraine;

    rnInstitute of Haematology and Transfusiology Academy of Medical Sciences of Ukraine, Kiev, Ukraine;

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