BIOLOGICAL INDICATION AND DOSIMETRY BASED ON THE FREQUENCY OF UNSTABLE ABERRATIONS OF CHROMOSOMES IN HUMAN LYMPHOCYTES

I.R. Barylyak; E.A. Demina

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BIOLOGICAL INDICATION AND DOSIMETRY BASED ON THE FREQUENCY OF UNSTABLE ABERRATIONS OF CHROMOSOMES IN HUMAN LYMPHOCYTES

机译：基于人类淋巴细胞染色体不稳定异常频率的生物指示和剂量学

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The present review deals with issues of biological (cytogenetic) dosimetry and indication of the degree of radiation injury based on analysis of unstable aberrations of chromosomes in human blood lymphocytes. We have also considered criteria, which determine the use of lymphocyte culture of human peripheral blood as an informative and actual indicator of radiation injury. We pay much attention to effects produced by low-level radiation doses in chromosomes and discuss methodology of interpreting the nature of dose cytogenetic curves. Traditional cytogenetic analysis (in terms of stable chromosomal aberrations) is a basic tool for cytogenetic monitoring in groups of people accidentally exposed to radiation and identification of groups of high risk of pathology including oncological one.

机译：本综述基于人类血液淋巴细胞染色体不稳定像差的分析，探讨了生物学（细胞遗传学）剂量测定法和辐射损伤程度的指标。我们还考虑了一些标准，这些标准决定了使用人类外周血淋巴细胞培养作为放射损伤的信息和实际指标。我们非常关注染色体上低剂量辐射产生的效应，并讨论了解释剂量细胞遗传曲线性质的方法。传统的细胞遗传学分析（就稳定的染色体畸变而言）是对意外暴露于辐射的人群进行细胞遗传学监测以及鉴定包括肿瘤学在内的高病理风险人群的基本工具。

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《Cytology and genetics》 |2004年第1期|p.65-77|共13页
作者
I.R. Barylyak; E.A. Demina;
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Scientific Center of Medical Genetics, Academy of Medical Sciences of Ukraine, Kyiv;

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正文语种 eng
中图分类普通生物学;
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1. Biological indication and dosymetry of unstable chromosome aberration frequencies in human lymphocytes [J] . Barylyak I. R., Demina E. A. Цитология и генетика: Науч. журн. . 2004,第1期

机译：人淋巴细胞不稳定染色体畸变频率的生物学指示和剂量测定
2. Biological indication and dosymetry of unstable chromosome aberration frequencies in human lymphocytes [J] . Barylyak I. R., Demina E. A. Цитология и генетика: Науч. журн. . 2004,第1期

机译：人淋巴细胞中不稳定染色体畸变频率的生物学指示及致少算法
3. Induction and persistence of chromosome Aberrations in human lymphocytes exposed to Neutrons in vitro or in vivo: implications of Findings in 'Retrospective' Biological dosimetry [J] . L.G. Littlefiedl, A.F. McFee, A.M. Sayer Radiation Protection Dosimetry . 2000,第1期

机译：体外或体内暴露于中子的人淋巴细胞中染色体畸变的诱导和持久性：“回顾性”生物剂量学研究结果的意义
4. BIOLOGICAL DOSIMETRY OF ABSORBED RADIATION DOSE BASED ON THE FREQUENCIES OF CHROMOSOMAL ABERRATIONS IN HUMAN LYMPHOCYTES [C] . NATO advanced research workshop on fundamentals for the assessment of risks from environmental radiation . 1999

机译：基于人淋巴细胞染色体畸变频率的吸收辐射剂量的生物剂量测量
5. Human immunoglobulin lambda light chain genes and lambda-like genes: Identification and characterization of a new C lambda gene and chromosomal localization and expression of human lambda-like genes in pre-B lymphocytes. [D] . Bauer, Thomas Roy, Jr. 1992

机译：人免疫球蛋白λ轻链基因和λ样基因：新的Cλ基因的鉴定和表征以及前λB淋巴细胞中人λ样基因的染色体定位和表达。
6. Chromosome painting in biological dosimetry: assessment of the ability to score stable chromosome aberrations using different pairs of paint probes. [O] . J M García Sagredo, I Vallcorba, López-Yarto, 1996

机译：生物剂量学中的染色体绘画：使用不同的绘画探针对评估稳定染色体畸变的能力的评估。
7. Estimation of relative biological effectiveness of 6 and 22 MeV neutrons and 137Cs γ-rays based on the analysis of chromosome aberrations in human peripheral blood lymphocytes [O] . Dyomina Emilia A., Ryabchenko Natalia M., Voitsitskyi Volodymyr M., 2005

机译：基于人外周血淋巴细胞染色体畸变的分析，估算6和22 MeV中子和137Csγ射线的相对生物学有效性

BIOLOGICAL INDICATION AND DOSIMETRY BASED ON THE FREQUENCY OF UNSTABLE ABERRATIONS OF CHROMOSOMES IN HUMAN LYMPHOCYTES

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