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首页> 外文期刊>Cytology and genetics >FEATURES OF X-CHROMOSOME INACTIVATION AMONG ELDERLY WOMEN OVER THE AGE OF 70
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FEATURES OF X-CHROMOSOME INACTIVATION AMONG ELDERLY WOMEN OVER THE AGE OF 70

机译：70岁以上老年人X染色体灭活的特征

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摘要

Features of X-chromosome inactivation among 40 women aged 74 to 85 are investigated, while 36 women (mean age 30) are studied as a control group. A generally accepted method of methyl-sensitive restriction and subsequent quantitative polymerase chain reaction analysis of the (CAG)_n repeat expansion of the androgen receptor gene (HUMARA) are used. We did not discover any dependence of features of X-chromosome inactivation on age. In particular, in the group of elderly females only three of the 40 subjects (7.5%) had unequal X inactivation by comparison with two of the 36 women (5.5%) in the control group. A comparison of the data obtained here with published data shows that the difference in the estimation of X-chromosome inactivation of different age groups may be related to a number of procedural errors, that is, the high age heterogeneity of the groups studied; inclusion in the investigation of women with different genetic impairments, leading to a shift in inactivation; as well as different limits of differentiation between equal and unequal X-chromosome inactivation.
机译：调查了40名74至85岁女性中X染色体失活的特征，同时以36名女性（平均年龄30岁）为对照组。使用一种普遍接受的甲基敏感限制性酶切方法，然后对雄激素受体基因（HUMARA）的（CAG）_n重复扩增进行定量聚合酶链反应分析。我们没有发现X染色体失活特征对年龄的任何依赖性。特别是，在老年女性组中，与对照组的36名女性中的两名女性（5.5％）相比，40名受试者中只有三名（7.5％）具有不相等的X失活。将此处获得的数据与已发表的数据进行比较，结果表明，不同年龄组的X染色体失活估计值的差异可能与许多程序错误有关，也就是说，所研究组的年龄异质性较高。纳入对具有不同遗传缺陷的妇女的调查中，从而导致失活的转变；以及相等和不相等的X染色体失活之间差异的不同限制。

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