...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytology and genetics >Study on Effects of Ag-SiO_2 Core Shell Nanoparticles on Biocompatibility Appraisal of Myoblasts
【24h】

Study on Effects of Ag-SiO_2 Core Shell Nanoparticles on Biocompatibility Appraisal of Myoblasts

机译：Ag-SiO_2核心壳纳米粒子对肌细胞生物相容性评估的影响研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The main goal of present study was to check interaction of Ag-SiO2 core shell nanoparticles (CSNs) with C2C12 cells. We herein account the synthesis and classification of novel CSNs. We aimed the preparation of CSNs in order to check their biocompatible/cytotoxic impact on C2C12 muscle cells. We aimed to check the CSNs related hazards to human health. The utilized CSNs were synthesized by the straightforward sol-gel method utilizing silver nitrate and tetraethoxysilane as fundamental components. The physicochemical characterization of the CSNs was conceded by means of X-ray diffraction, UV-Vis and transmission electron microscopy. To examine in vitro biocompatibility/cytotoxicity, C2C12 cells were cultured under in vitro environment and afterward subjected to different concentrations of CSNs. The survival of C2C12 cells was evaluated via cell counting Kit-8 assay at exact point gap. These results were authenticated by confocal microscopy. The morphology of C2C12 cells was observed with the help of a phase contrast microscope. In vitro investigation of biological effects of CSNs has revealed that feasibility of cells in culture follows dose (0-20 mu g/mL) mode. Overall, results of this investigation demonstrate that synthetic CSNs influence C2C12 cell practicability with time point as well as absorption dependent mode.
机译：本研究的主要目的是检查Ag-SiO2核壳纳米颗粒（CSN）与C2C12细胞的相互作用。我们在这里考虑了新型CSN的合成和分类。我们旨在制备CSN，以检查它们对C2C12肌细胞的生物相容性/细胞毒性的影响。我们旨在检查CSNS对人体健康有关的危害。利用硝酸银和四乙氧基硅烷作为基本组分的直接溶胶 - 凝胶法合成使用的CSN。通过X射线衍射，UV-VI和透射电子显微镜检查CSN的物理化学表征。为了在体外生物相容性/细胞毒性，在体外环境下培养C2C12细胞，然后经过不同浓度的CSN培养。通过细胞计数试剂盒-8测定在精确点间隙下评估C2C12细胞的存活。这些结果通过共聚焦显微镜进行了认证。借助相对造影显微镜观察C2C12细胞的形态。对CSNS的生物学作用的体外调查揭示了培养细胞的可行性遵循剂量（0-20μg/ ml）模式。总体而言，该研究的结果表明，合成CSNS在时间点以及吸收依赖性模式中影响C2C12细胞实用性。

著录项

  • 来源
    《Cytology and genetics》 |2021年第2期|199-204|共6页
  • 作者

    Amna Touseef; Alghamdi Abdullah A. A.; Khan Rizwan; Hassan M. Shamshi; Khil Myung-Seob;

  • 作者单位

    Albaha Univ Dept Biol & Biotechnol Fac Sci Albaha 1988 Saudi Arabia;

    Albaha Univ Dept Biol Fac Sci Albaha 1988 Saudi Arabia;

    Chonbuk Natl Univ Sch Adv Mat Engn Jeonju 561756 South Korea|Chonbuk Natl Univ Res Ctr Adv Mat Dev Jeonju 561756 South Korea;

    Albaha Univ Dept Chem Fac Sci Albaha 1988 Saudi Arabia|Jeonbuk Natl Univ Dept Organ Mat & Fiber Engn Jeonju 561756 South Korea;

    Albaha Univ Dept Chem Fac Sci Albaha 1988 Saudi Arabia;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    core shell; nanomedicine; nanoparticles; silica;

    机译：核心壳;纳米胺;纳米颗粒;二氧化硅;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号