Quantitative discrimination of biological tissues by micro-elastographic measurement using an epi-illumination Mueller matrix microscope

Pradipta Mukherjee; Tomohisa Horiguchi; Shuhei Shibata; Nathan Hagen; Yukitoshi Otani

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Quantitative discrimination of biological tissues by micro-elastographic measurement using an epi-illumination Mueller matrix microscope

机译：使用落射照明Mueller矩阵显微镜通过微弹性成像测量对生物组织进行定量判别

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摘要

We propose a method for estimating the stiffness of bio-specimens by measuring their linear retardance properties under applied stress. For this purpose, we employ an epi-illumination Mueller matrix microscope and show the procedures for its calibration. We provide experimental results demonstrating how to apply Mueller matrix data to elastography, using chicken liver and chicken heart as biological samples. Finally, we show how the histograms of linear retardance images can be used to distinguish between specimens and quantify the discrimination accuracy.

机译：我们提出了一种通过测量生物样品在施加应力下的线性延迟特性来估算其刚度的方法。为此，我们使用落射照明Mueller矩阵显微镜并显示了其校准过程。我们提供了实验结果，展示了如何使用鸡肝和鸡心作为生物样本将Mueller矩阵数据应用于弹性成像。最后，我们展示了线性延迟图像的直方图如何用于区分样本和量化判别精度。

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《Biomedical Optics Express》 |2019年第8期|共13页
作者
Pradipta Mukherjee; Tomohisa Horiguchi; Shuhei Shibata; Nathan Hagen; Yukitoshi Otani;
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中图分类生物科学;
关键词
Image processingImaging techniquesMueller matricesOptical coherence tomographyPolarimetric imagingStress birefringence;

机译：图像处理成像技术穆勒矩阵光学相干断层扫描多色成像应力双折射;

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专利

1. Mueller matrix microscope: a quantitative tool to facilitate detections and fibrosis scorings of liver cirrhosis and cancer tissues [J] . Ye Wang, Honghui He, Jintao Chang, Journal of biomedical optics . 2016,第7期

机译：Mueller矩阵显微镜：一种定量工具，可促进肝硬化和癌组织的检测和纤维化评分
2. Quantitative mueller matrix polarimetry techniques for biological tissues [J] . He H, Zeng N., Li D., Journal of innovative optical health sciences . 2012,第3期

机译：生物组织的定量穆勒矩阵极化技术
3. QUANTITATIVE MUELLER MATRIX POLARIMETRY TECHNIQUES FOR BIOLOGICAL TISSUES [J] . MA HUI, LI DONGZHI, LIAO RAN, Journal of innovative optical health sciences . 2012,第03期

机译：生物组织的定量穆勒矩阵极化技术
4. Quantitative detection of breast ductal carcinoma tissues at different progression stages using Mueller matrix microscope [C] . Teng Liu, Honghui He, Yang Dong, Dynamics and fluctuations in biomedical photonics XV . 2018

机译：使用Mueller矩阵显微镜定量检测不同进展阶段的乳腺导管癌组织
5. THIN FILM MEASUREMENTS ON ROUGH SUBSTRATES USING MUELLER MATRIX ELLIPSOMETRY [D] . RAMSEY, DAVID ANDREW 1985

机译：使用MUELLER矩阵椭偏仪对粗糙基体进行薄膜测量
6. Quantitative discrimination of biological tissues by micro-elastographic measurement using an epi-illumination Mueller matrix microscope [O] . Pradipta Mukherjee, Tomohisa Horiguchi, Shuhei Shibata, 2019

机译：使用落射照明Mueller矩阵显微镜通过微弹性成像测量对生物组织进行定量判别
7. Quantitative discrimination of biological tissues by micro-elastographic measurement using an epi-illumination Mueller matrix microscope [O] . Pradipta Mukherjee, Tomohisa Horiguchi, Shuhei Shibata, 2019

机译：使用EPI照明ueller基质显微镜通过微弹性测量来定量辨别生物组织

Quantitative discrimination of biological tissues by micro-elastographic measurement using an epi-illumination Mueller matrix microscope

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