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首页> 外文期刊>Journal of biomedical optics >Mueller matrix microscope: a quantitative tool to facilitate detections and fibrosis scorings of liver cirrhosis and cancer tissues
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Mueller matrix microscope: a quantitative tool to facilitate detections and fibrosis scorings of liver cirrhosis and cancer tissues

机译：Mueller矩阵显微镜：一种定量工具，可促进肝硬化和癌组织的检测和纤维化评分

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摘要

Today the increasing cancer incidence rate is becoming one of the biggest threats to human health. Among all types of cancers, liver cancer ranks in the top five in both frequency and mortality rate all over the world. During the development of liver cancer, fibrosis often evolves as part of a healing process in response to liver damage, resulting in cirrhosis of liver tissues. In a previous study, we applied the Mueller matrix microscope to pathological liver tissue samples and found that both the Mueller matrix polar decomposition (MMPD) and Mueller matrix transformation (MMT) parameters are closely related to the fibrous microstructures. In this paper, we take this one step further to quantitatively facilitate the fibrosis detections and scorings of pathological liver tissue samples in different stages from cirrhosis to cancer using the Mueller matrix microscope. The experimental results of MMPD and MMT parameters for the fibrotic liver tissue samples in different stages are measured and analyzed. We also conduct Monte Carlo simulations based on the sphere birefringence model to examine in detail the influence of structural changes in different fibrosis stages on the imaging parameters. Both the experimental and simulated results indicate that the polarized light microscope and transformed Mueller matrix parameters can provide additional quantitative information helpful for fibrosis detections and scorings of liver cirrhosis and cancers. Therefore, the polarized light microscope and transformed Mueller matrix parameters have a good application prospect in liver cancer diagnosis.
机译：今天，不断增加的癌症发病率正成为对人类健康的最大威胁之一。在所有类型的癌症中，肝癌的发病率和死亡率均居世界前五位。在肝癌的发展过程中，纤维化通常作为对肝脏损伤的治愈过程的一部分而演变，导致肝组织肝硬化。在先前的研究中，我们将Mueller矩阵显微镜应用于病理性肝组织样本，发现Mueller矩阵极性分解（MMPD）和Mueller矩阵变换（MMT）参数均与纤维微结构密切相关。在本文中，我们迈出了进一步的一步，使用Mueller矩阵显微镜定量地定量了从肝硬化到癌症不同阶段的病理性肝组织样品的纤维化检测和评分。测量并分析了不同阶段的肝纤维化样品的MMPD和MMT参数的实验结果。我们还根据球面双折射模型进行了蒙特卡洛模拟，以详细检查不同纤维化阶段的结构变化对成像参数的影响。实验结果和模拟结果均表明，偏光显微镜和变换后的Mueller矩阵参数可以提供更多的定量信息，有助于纤维化检测和肝硬化和癌症评分。因此，偏光显微镜和变换的Mueller矩阵参数在肝癌诊断中具有良好的应用前景。

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  • 来源
    《Journal of biomedical optics》 |2016年第7期|071112.1-071112.9|共9页
  • 作者

    Ye Wang; Honghui He; Jintao Chang; Chao He; Shaoxiong Liu; Migao Li; Nan Zeng; Jian Wu; Hui Ma;

  • 作者单位

    Tsinghua University, Graduate School at Shenzhen, Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, 2279 Lishui Street, Shenzhen 518055, China,Tsinghua University, Department of Physics, 1 Tsinghua Yuan, Beijing 100084, China;

    Tsinghua University, Graduate School at Shenzhen, Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, 2279 Lishui Street, Shenzhen 518055, China;

    Tsinghua University, Graduate School at Shenzhen, Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, 2279 Lishui Street, Shenzhen 518055, China,Tsinghua University, Department of Physics, 1 Tsinghua Yuan, Beijing 100084, China;

    Tsinghua University, Graduate School at Shenzhen, Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, 2279 Lishui Street, Shenzhen 518055, China,Tsinghua University, Department of Biomedical Engineering, 1 Tsinghua Yuan, Beijing 100084, China;

    Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen Sixth People's Hospital (Nanshan Hospital), 89 Taoyuan Street, Shenzhen 518052, China;

    Guangzhou Liss Optical Instrument Factory, 81 Taojinbei Street, Guangzhou 510095, China;

    Tsinghua University, Graduate School at Shenzhen, Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, 2279 Lishui Street, Shenzhen 518055, China;

    Tsinghua University, Graduate School at Shenzhen, Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, 2279 Lishui Street, Shenzhen 518055, China;

    Tsinghua University, Graduate School at Shenzhen, Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, 2279 Lishui Street, Shenzhen 518055, China,Tsinghua University, Department of Physics, 1 Tsinghua Yuan, Beijing 100084, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Mueller matrix; microscope; polarization; liver cancer; fibrosis;

    机译：穆勒矩阵;显微镜;偏振;肝癌;纤维化;

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