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首页> 外文期刊>Biomarker Insights >Biomarkers of Dose and Effect of Inhaled Ozone in Resting versus Exercising Human Subjects: Comparison with Resting Rats:
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Biomarkers of Dose and Effect of Inhaled Ozone in Resting versus Exercising Human Subjects: Comparison with Resting Rats:

机译：静息与运动人体受试者的剂量和吸入臭氧作用的生物标志物：与静息大鼠的比较：

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To determine the influence of exercise on pulmonary dose of inhaled pollutants, we compared biomarkers of inhaled ozone (O_(3)) dose and toxic effect between exercise levels in humans, and between humans and rats. Resting human subjects were exposed to labeled O_(3) (~(18)O_(3), 0.4 ppm, for 2 hours) and alveolar O_(3) dose measured as the concentration of excess ~(18)O in cells and extracellular material of nasal, bronchial, and bronchoalveolar lavage fluid (BALF). We related O_(3) dose to effects (changes in BALF protein, LDH, IL-6, and antioxidant substances) measurable in the BALF. A parallel study of resting subjects examined lung function (FEV_(1)) changes following O_(3). Subjects exposed while resting had ~(18)O concentrations in BALF cells that were 1/5th of those of exercising subjects and directly proportional to the amount of O_(3) breathed during exposure. Quantitative measures of alveolar O_(3) dose and toxicity that were observed previously in exercising subjects were greatly reduced or non-observable in O_(3) exposed resting subjects. Resting rats and resting humans were found to have a similar alveolar O_(3) dose.
机译：为了确定运动对吸入污染物的肺部剂量的影响，我们比较了人与人之间以及人与大鼠之间的吸入臭氧（O_（3））剂量和毒性效应的生物标志物。静息的人类受试者暴露于标记的O_（3）（〜（18）O_（3），0.4 ppm，2小时），肺泡O_（3）剂量以细胞和细胞外过量〜（18）O的浓度测量鼻，支气管和支气管肺泡灌洗液（BALF）的材料。我们将O_（3）剂量与在BALF中可测量的效果（BALF蛋白，LDH，IL-6和抗氧化剂物质的变化）相关。对静息受试者的一项平行研究检查了O_（3）之后肺功能（FEV_（1））的变化。休息时暴露的受试者的BALF细胞中〜（18）O浓度为运动受试者的1/5，并且与暴露期间呼吸的O_（3）量成正比。先前在运动受试者中观察到的肺泡O_（3）剂量和毒性的定量测量在暴露于O_（3）的静息受试者中大大降低或无法观察到。发现静息的大鼠和静息的人具有相似的肺泡O_（3）剂量。

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