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首页> 外文期刊>Biomaterials Research >Rapid bone regeneration by Escherichia coli-derived recombinant human bone morphogenetic protein-2 loaded on a hydroxyapatite carrier in the rabbit calvarial defect model
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Rapid bone regeneration by Escherichia coli-derived recombinant human bone morphogenetic protein-2 loaded on a hydroxyapatite carrier in the rabbit calvarial defect model

机译：在兔颅盖缺损模型中，大肠杆菌衍生的重组人骨形态发生蛋白-2负载在羟基磷灰石载体上的快速骨再生

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BackgroundThe aim of this study was to determine the osteoconductivity of hydroxyapatite particles (HAP) as a carrier for Escherichia coli -derived recombinant human bone morphogenetic protein-2 (ErhBMP-2). Two 8-mm diameter bicortical calvarial defects were created in each of 20 rabbits. One of each pair of defects was randomly assigned to be filled with HAP only (HAP group) or ErhBMP-2 loaded HAP (ErhBMP-2/HAP group), while the other defect was left untreated (control group). The animals were killed after either 2?weeks ( n =?10) or 8?weeks ( n =?10) of healing, and histological, histomorphometric, and tomographic analyses were performed. ResultsAll experimental sites showed uneventful healing during the postoperative healing period. In both histomorphometric and tomographic analyses, the new bone area or volume of the ErhBMP-2/HAP group was significantly greater than that of the HAP and control groups at 2?weeks ( p ConclusionsCombining ErhBMP-2 with HAP could significantly promote rapid initial new bone formation. Moreover, HAP graft could increase new bone formation and space maintenance, therefore it might be one of the effective carriers of ErhBMP-2.
机译：背景本研究的目的是确定羟基磷灰石颗粒（HAP）作为大肠杆菌衍生的重组人骨形态发生蛋白2（ErhBMP-2）载体的骨电导率。在20只兔中，每只产生两个8mm直径的双皮质颅盖缺损。每对缺陷中的一个被随机分配为仅用HAP填充（HAP组）或装载有ErhBMP-2的HAP（ErhBMP-2 / HAP组），而另一个缺陷未经处理（对照组）。在愈合2周（n = 10）或8周（n = 10）后杀死动物，并进行组织学，组织形态学和断层扫描分析。结果所有实验部位在术后愈合期间均表现出良好的愈合。在组织形态计量学和断层扫描分析中，ErhBMP-2 / HAP组在2周时的新骨面积或体积均显着大于HAP和对照组（p结论）。而且，HAP移植物可以增加新的骨形成和空间维持，因此它可能是ErhBMP-2的有效载体之一。

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