• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biological Procedures Online >A Method for Structure–Activity Analysis of Quorum-Sensing Signaling Peptides from Naturally Transformable Streptococci
【24h】

A Method for Structure–Activity Analysis of Quorum-Sensing Signaling Peptides from Naturally Transformable Streptococci

机译：一种天然可转化链球菌群体感应信号肽的结构活性分析方法

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Many species of streptococci secrete and use a competence-stimulating peptide (CSP) to initiate quorum sensing for induction of genetic competence, bacteriocin production, and other activities. These signaling molecules are small, unmodified peptides that induce powerful strain-specific activity at nano-molar concentrations. This feature has provided an excellent opportunity to explore their structure–function relationships. However, CSP variants have also been identified in many species, and each specifically activates its cognate receptor. How such minor changes dramatically affect the specificity of these peptides remains unclear. Structure–activity analysis of these peptides may provide clues for understanding the specificity of signaling peptide–receptor interactions. Here, we use the Streptococcus mutans CSP as an example to describe methods of analyzing its structure–activity relationship. The methods described here may provide a platform for studying quorum-sensing signaling peptides of other naturally transformable streptococci.
机译：许多种链球菌都分泌并使用一种能力刺激肽（CSP）来启动群体感应，以诱导遗传能力，细菌素产生和其他活动。这些信号分子是小的未修饰的肽，可在纳摩尔浓度下诱导强大的菌株特异性活性。此功能为探索其结构与功能之间的关系提供了绝佳的机会。但是，CSP变体也已在许多物种中得到鉴定，并且每个都特异性激活其同源受体。尚不清楚这种微小变化如何显着影响这些肽的特异性。这些肽的结构-活性分析可能为理解信号肽-受体相互作用的特异性提供线索。在这里，我们以变形链球菌CSP为例，描述分析其结构-活性关系的方法。本文所述方法可为研究其他自然可转化链球菌的群体感应信号肽提供一个平台。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号