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首页> 外文期刊>Biomedical Optics Express >Integrated photoacoustic, ultrasound and fluorescence platform for diagnostic medical imaging-proof of concept study with a tissue mimicking phantom
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Integrated photoacoustic, ultrasound and fluorescence platform for diagnostic medical imaging-proof of concept study with a tissue mimicking phantom

机译：集成的光声，超声和荧光平台可用于诊断医学成像，并具有组织模拟体模的概念研究证明

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摘要

The structural and molecular heterogeneities of biological tissues demand the interrogation of the samples with multiple energy sources and provide visualization capabilities at varying spatial resolution and depth scales for obtaining complementary diagnostic information. A novel multi-modal imaging approach that uses optical and acoustic energies to perform photoacoustic, ultrasound and fluorescence imaging at multiple resolution scales from the tissue surface and depth is proposed in this paper. The system comprises of two distinct forms of hardware level integration so as to have an integrated imaging system under a single instrumentation set-up. The experimental studies show that the system is capable of mapping high resolution fluorescence signatures from the surface, optical absorption and acoustic heterogeneities along the depth (2cm) of the tissue at multi-scale resolution (1µm to 0.5mm).
机译：生物组织的结构和分子异质性要求使用多种能源对样品进行询问，并在变化的空间分辨率和深度范围内提供可视化功能，以获得互补的诊断信息。本文提出了一种新颖的多模态成像方法，该方法利用光能和声能从组织表面和深度以多个分辨率范围执行光声，超声和荧光成像。该系统包括两种不同形式的硬件级别集成，以便在单个仪器设置下具有集成的成像系统。实验研究表明，该系统能够以多尺度分辨率（<1µm至<0.5mm）沿着组织的深度（> 2cm）从表面，光学吸收和声学异质性绘制高分辨率荧光特征。

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