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首页> 外文期刊>Biomarker Research >Erythrocyte fatty acid profiles in children are not predictive of autism spectrum disorder status: a case control study
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Erythrocyte fatty acid profiles in children are not predictive of autism spectrum disorder status: a case control study

机译：儿童的红细胞脂肪酸谱不能预测自闭症谱系障碍的状态：一项病例对照研究

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Biomarkers promise biomolecular explanations as well as reliable diagnostics, stratification, and treatment strategies that have the potential to help mitigate the effects of disorders. While no reliable biomarker has yet been found for autism spectrum disorder (ASD), fatty acids have been investigated as potential biomarkers because of their association with brain development and neural functions. However, the ability of fatty acids to classify individuals with ASD from age/gender-matched neurotypical (NEU) peers has largely been ignored in favor of investigating population-level differences. Contrary to existing work, this classification task between ASD and NEU cohorts is the main focus of this work. The data presented herein suggest that fatty acids do not allow for classification at the individual level.
机译：生物标记物有望提供生物分子的解释以及可靠的诊断，分层和治疗策略，从而有可能帮助减轻疾病的影响。尽管尚未发现自闭症谱系障碍（ASD）的可靠生物标志物，但由于脂肪酸与大脑发育和神经功能有关，因此脂肪酸已被研究为潜在的生物标志物。然而，为了研究人群水平的差异，脂肪酸从年龄/性别匹配的神经型（NEU）同伴中分类为ASD个体的能力已被大大忽略。与现有工作相反，ASD和NEU队列之间的分类任务是这项工作的主要重点。本文提供的数据表明脂肪酸不允许在个体水平上分类。

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