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首页> 外文期刊>BioResearch open access. >Treating Proximal Tibial Growth Plate Injuries Using Poly(Lactic-co-Glycolic Acid) Scaffolds
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Treating Proximal Tibial Growth Plate Injuries Using Poly(Lactic-co-Glycolic Acid) Scaffolds

机译：聚乳酸-乙醇酸支架治疗胫骨近端生长板损伤

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摘要

Growth plate fractures account for nearly 18.5% of fractures in children. Depending on the type and severity of the injury, inhibited bone growth or angular deformity caused by bone forming in place of the growth plate can occur. The current treatment involves removal of the bony bar and replacing it with a filler substance, such as a free fat graft. Unfortunately, reformation of the bony bar frequently occurs, preventing the native growth plate from regenerating. The goal of this pilot study was to determine whether biodegradable scaffolds can enhance native growth plate regeneration following a simulated injury that resulted in bony bar formation in the proximal tibial growth plate of New Zealand white rabbits. After removing the bony bar, animals received one of the following treatments: porous poly(lactic-co-glycolic acid) (PLGA) scaffold; PLGA scaffold loaded with insulin-like growth factor I (IGF-I); PLGA scaffold loaded with IGF-I and seeded with autogenous bone marrow cells (BMCs) harvested at the time of implantation; or fat graft (as used clinically). The PLGA scaffold group showed an increased chondrocyte population and a reduced loss of the remaining native growth plate compared to the fat graft group (the control group). An additional increase in chondrocyte density was seen in scaffolds loaded with IGF-I, and even more so when BMCs were seeded on the scaffold. While there was no significant reduction in the angular deformation of the limbs, the PLGA scaffolds increased the amount of cartilage and reduced the amount of bony bar reformation.
机译：生长板骨折占儿童骨折的近18.5％。根据损伤的类型和严重程度，可能会出现由骨形成代替生长板引起的骨生长受抑制或角畸形。当前的治疗包括去除骨棒，并用填充剂，例如游离脂肪移植物代替。不幸的是，经常发生骨棒的再形成，从而阻止了天然生长板的再生。这项初步研究的目的是确定在模拟损伤后可生物降解的支架是否能增强天然生长板的再生，该损伤导致新西兰白兔近端胫骨生长板中形成骨棒。取下骨棒后，动物接受以下处理之一：多孔聚乳酸-乙醇酸共聚物（PLGA）支架;载有胰岛素样生长因子I（IGF-I）的PLGA支架; PLGA支架上装有IGF-I，并植入了植入时收获的自体骨髓细胞（BMC）;或脂肪移植物（临床使用）。与脂肪移植组（对照组）相比，PLGA支架组的软骨细胞数量增加，而剩余的天然生长板的损失减少。在载有IGF-I的支架中，软骨细胞密度进一步增加，当将BMC接种在支架上时，软骨细胞密度进一步增加。尽管四肢的角变形没有明显减少，但PLGA支架增加了软骨的数量，减少了骨棒再形成的数量。

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