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An Autologous Muscle Tissue Expansion Approach for the Treatment of Volumetric Muscle Loss

机译：自体肌肉组织扩张方法治疗体积性肌肉丢失

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Volumetric muscle loss (VML) is a hallmark of orthopedic trauma with no current standard of care. As a potential therapy for some VML indications, autologous minced muscle grafts (1?mm3 pieces of muscle) are effective in promoting remarkable de novo fiber regeneration. But they require ample donor muscle tissue and therefore may be limited in their application for large clinical VML. Here, we tested the hypothesis that autologous minced grafts may be volume expanded in a collagen hydrogel, allowing for the use of lesser autologous muscle while maintaining regenerative and functional efficacy. The results of the study indicate that 50% (but not 75%) less minced graft tissue suspended in a collagen hydrogel promoted a functional improvement similar to that of a 100% minced graft repair. However, approximately half of the number of fibers regenerated de novo with 50% graft repair. Moreover, the fibers that regenerated had a smaller cross-sectional area. These findings support the concept of using autologous minced grafts for the regeneration of muscle tissue after VML, but indicate the need to identify optimal carrier materials for expansion.
机译：体积性肌肉丢失（VML）是目前没有标准护理的骨科创伤的标志。作为某些VML适应症的潜在疗法，自体切碎的肌肉移植物（1？mm 3 块肌肉）可有效促进显着的新生纤维再生。但是它们需要足够的供体肌肉组织，因此可能不适用于大型临床VML。在这里，我们测试了这样一种假说，即自体切碎的移植物可能在胶原蛋白水凝胶中体积扩大，从而允许使用较少的自体肌肉，同时保持再生和功能功效。研究结果表明，悬浮在胶原蛋白水凝胶中的切碎的移植物组织减少了50％（但不是75％），其功能改善类似于100％切碎的移植物修复。但是，大约有一半数量的纤维从头开始进行再生，修复率达50％。此外，再生的纤维具有较小的横截面积。这些发现支持在VML后使用自体切碎的移植物再生肌肉组织的概念，但表明需要确定最佳的扩张用载体材料。

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