The APPEESFRS Peptide, Restricted by the HLA-B*35:01 Molecule, and the APPEESFRF Variant Derived from an Autologous HIV-1 Strain Induces Polyfunctional Responses in CD8+ T Cells

Liliana Acevedo-Sáenz; Liseth Carmona-Pérez; Paula Andrea Velilla-Hernández; Julio C. Delgado; María Teresa Rugeles L.

首页> 外文期刊>BioResearch open access. >The APPEESFRS Peptide, Restricted by the HLA-B*35:01 Molecule, and the APPEESFRF Variant Derived from an Autologous HIV-1 Strain Induces Polyfunctional Responses in CD8+ T Cells

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The APPEESFRS Peptide, Restricted by the HLA-B*35:01 Molecule, and the APPEESFRF Variant Derived from an Autologous HIV-1 Strain Induces Polyfunctional Responses in CD8+ T Cells

机译：受HLA-B * 35：01分子限制的APPEESFRS肽和自体HIV-1株衍生的APPEESFRF变异体诱导CD8 + T细胞中的多功能反应

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Numerous reports have focused on consensus peptides to determine CD8+ T-cell responses; however, few studies evaluated the functional profile using peptides derived from circulating strains of a specific region. We determined the effector profile and maturation phenotype of CD8+ T-cells targeting the consensus APPEESFRS (AS9) epitope and its variant APPEESFRF (AF9), previously identified. The free energy of binding, maturation phenotype, and polyfunctional profile of both peptides were similar. The magnitude of CD8+ T-cell responses to AF9 was greater than the one elicited by AS9, although the difference was not significant. The polyfunctional profile of AF9 was characterized by CD107a/interleukin-2 (IL-2)/macrophage inflammatory protein beta (MIP1β) and by interferon gamma (IFNγ)/MIP1β/tumor necrosis factor alpha (TNFα) in response to AS9. TNFα production was significantly higher in response to AF9 than to AS9, and there was a negative correlation between the absolute number of CD8+ T-cell-producing TNFα and the plasma human immunodeficiency virus (HIV) load, suggesting a role of this cytokine in the control of HIV replication.

机译：许多报告集中在确定CD8 + T细胞反应的共有肽上。然而，很少有研究使用衍生自特定区域循环菌株的肽评估功能概况。我们确定了靶向共有APPEESFRS（AS9）表位及其变异APPEESFRF（AF9）的CD8 + T细胞的效应子概况和成熟表型，之前已确定。两种肽的结合自由能，成熟表型和多官能谱相似。 CD8 + T细胞对AF9的反应强度大于AS9引起的反应，尽管差异并不显着。 AF9的多功能性特征是CD107a /白介素2（IL-2）/巨噬细胞炎性蛋白β（MIP1β）和干扰素γ（IFNγ）/MIP1β/肿瘤坏死因子α（TNFα）对AS9的响应。对AF9的应答中，TNFα的产生显着高于对AS9的应答，并且CD8 + T细胞产生的TNFα的绝对数量与血浆人免疫缺陷病毒（HIV）负荷之间呈负相关，这表明该细胞因子在ADF中的作用。控制艾滋病毒的复制。

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《BioResearch open access.》 |2015年第1期|共15页
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Liliana Acevedo-Sáenz; Liseth Carmona-Pérez; Paula Andrea Velilla-Hernández; Julio C. Delgado; María Teresa Rugeles L.;
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中图分类细胞生物学;
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1. A human CTL recognizes a caspase-8-derived peptide on autologous HLA-B*3503 molecules and two unrelated peptides on allogeneic HLA-B*3501 molecules. [J] . Mandruzzato S, Stroobant V, Demotte N, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2000,第8期

机译：人CTL识别自体HLA-B * 3503分子上的caspase-8衍生肽和同种异体HLA-B * 3501分子上的两个无关肽。
2. A Human CTL Recognizes a Caspase-8-Derived Peptide on Autologous HLA-B*3503 Molecules and Two Unrelated Peptides on Allogeneic HLA-B*3501 Molecules [J] . Susanna Mandruzzato, Vincent Stroobant, Nathalie Demotte, The journal of immunology . 2000,第8期

机译：人类CTL识别自体HLA-B * 3503分子上的caspase-8衍生肽和同种异体HLA-B * 3501分子上的两个无关肽
3. HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: Novel versatile preclinical models of human T cell responses [J] . BouchermaR., Kridane-MilediH., BouziatR., The Journal of Immunology: Official Journal of the American Association of Immunologists . 2013,第2期

机译：HLA-A * 01：03，HLA-A * 24：02，HLA-B * 08：01，HLA-B * 27：05，HLA-B * 35：01，HLA-B * 44：02和HLA -C * 07：01单链转基因/ H-2 I类无效小鼠：人类T细胞反应的新型通用临床前模型
4. The APPEESFRS Peptide Restricted by the HLA-B*35:01 Molecule and the APPEESFRF Variant Derived from an Autologous HIV-1 Strain Induces Polyfunctional Responses in CD8+ T Cells [O] . Liliana Acevedo-Sáenz, Liseth Carmona-Pérez, Paula Andrea Velilla-Hernández, 2015

机译：受HLA-B * 35：01分子限制的APPEESFRS肽和自体HIV-1株衍生的APPEESFRF变体在CD8 + T细胞中诱导多功能反应
5. The APPEESFRS Peptide, Restricted by the HLA-B*35:01 Molecule, and the APPEESFRF Variant Derived from an Autologous HIV-1 Strain Induces Polyfunctional Responses in CD8+ T Cells [O] . Liliana Acevedo-Sáenz, Liseth Carmona-Pérez, Paula Andrea Velilla-Hernández, 2015

机译：由HLA-B * 35：01分子限制的AppeSFRS肽，并且来自自体HIV-1菌株的AppeSFRF变体诱导CD8 + T细胞中的多官能反应

The APPEESFRS Peptide, Restricted by the HLA-B*35:01 Molecule, and the APPEESFRF Variant Derived from an Autologous HIV-1 Strain Induces Polyfunctional Responses in CD8+ T Cells

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