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Serum Albumin Concentrations in a Multi-Ethnic Cohort of Patients with Human Immunodeficiency Virus Infection from South East London

机译:来自伦敦东南部的人类免疫缺陷病毒感染患者的多种族队列中的血清白蛋白浓度

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Human albumin is the most abundant protein in sera and a valuable biomarker in monitoring a variety of diseases. In this study we investigated the relationship between serum albumin concentrations and effects of initiation of highly active antiretroviral therapy (HAART). Serum albumin concentrations amongst 70 HIV-infected patients from diverse ethnicities were analyzed, in the absence of any other confounding comorbidities, over a period of 8 years in South East London, United Kingdom. Serum albumin data was collected, on average, every 4–6 weeks during routine visits. Serum albumin was measured prior to starting HAART, and measured at the first clinic visit after commencing HAART. These were compared to a control group of untreated individuals. Based on our analyses we conclude that serum albumin concentrations increase significantly after the initiation of therapy.
机译:人白蛋白是血清中最丰富的蛋白质,并且是监测各种疾病的宝贵生物标志物。在这项研究中,我们调查了血清白蛋白浓度与高活性抗逆转录病毒疗法(HAART)启动效果之间的关系。在不存在任何其他混淆性合并症的情况下,对英国东南伦敦在8年内的70名不同种族的HIV感染患者中的血清白蛋白浓度进行了分析。常规访视平均每4-6周收集一次血清白蛋白数据。在开始HAART之前先测量血清白蛋白,并在开始HAART之后的第一次就诊时进行测量。将这些与未治疗个体的对照组进行比较。根据我们的分析,我们得出结论,治疗开始后血清白蛋白浓度显着增加。

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