• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BioPsychoSocial Medicine >Effects of the α1-adrenoceptor agonist phenylephrine on SART stress-induced orthostatic hypotension in rats
【24h】

Effects of the α1-adrenoceptor agonist phenylephrine on SART stress-induced orthostatic hypotension in rats

机译：α1-肾上腺素受体激动剂去氧肾上腺素对SART应激引起的体位性低血压的影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Specific alternation of rhythm in temperature (SART)-stressed rats, an animal model of autonomic imbalance, exhibit low blood pressure and tachycardia during consciousness and under anesthesia. In addition, these rats easily develop orthostatic hypotension (OH) as a response to postural manipulation. Hence, we studied the influence of the adrenalin α1-receptor agonist phenylephrine on stress-induced OH in SART-stressed rats and unstressed rats. Methods Male Wistar rats weighing 250-300 g were used. Rats were fixed in the supine position under urethane anesthesia. Blood pressure was directly measured from the left common carotid artery and ECG was recorded simultaneously. Results The maximum decrease in blood pressure and the area under the blood pressure-time curve were both large, while the %reflex was small in the SART-stressed rats compared with unstressed rats. In the SART-stressed rats, prolonged intravenous administration of phenylephrine reduced OH at a dose that barely affected unstressed rats. Conclusion The results suggested that sympathetic dysfunction is a factor underlying SART stress-induced OH.
机译：背景压力（SART）应激大鼠的特定节律改变是一种自主神经失调的动物模型，在意识和麻醉状态下表现出低血压和心动过速。此外，这些大鼠容易对体位操作产生直立性低血压（OH）。因此，我们研究了肾上腺素α 1 -受体激动剂去氧肾上腺素对SART应激大鼠和非应激大鼠应激诱导的OH的影响。方法使用雄性Wistar大鼠，体重250-300 g。在氨基甲酸乙酯麻醉下将大鼠固定在仰卧位。从左颈总动脉直接测量血压，同时记录心电图。结果与无压力大鼠相比，SART压力大鼠的最大血压降低和在压力-时间曲线下的面积均大，而反射率则较小。在SART应激的大鼠中，长时间静脉内注射去氧肾上腺素可降低OH的剂量，而剂量几乎不会影响未应激的大鼠。结论结果表明，交感神经功能障碍是SART应激诱导的OH的基础。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号